J
Jochen Reiser
Researcher at Rush University Medical Center
Publications - 276
Citations - 19435
Jochen Reiser is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Podocyte & SuPAR. The author has an hindex of 60, co-authored 241 publications receiving 16499 citations. Previous affiliations of Jochen Reiser include Yeshiva University & Albert Einstein College of Medicine.
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Journal ArticleDOI
A Conditionally Immortalized Human Podocyte Cell Line Demonstrating Nephrin and Podocin Expression
Moin A. Saleem,Michael J O'Hare,Jochen Reiser,Richard J M Coward,Carol Inward,Timothy Farren,Chang Ying Xing,Lan Ni,Peter W. Mathieson,Peter Mundel +9 more
TL;DR: The development of this conditionally immortalized human podocyte cell line provides a new tool in the study of podocyte biology, which will enable accurate assessment of the behavior of these complex cells in health and disease.
Journal ArticleDOI
Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines
Peter Mundel,Jochen Reiser,Aimée Zúñiga Mejı́a Borja,Hermann Pavenstädt,Gary Davidson,Wilhelm Kriz,Rolf Zeller +6 more
TL;DR: The determinative steps of podocyte differentiation and process formation are studied for the first time using an inducible in vitro model and electrophysiological studies demonstrate that differentiated MPC cells respond to the vasoactive peptide bradykinin by changes in intracellular calcium concentration.
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The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
Christian Faul,Mary Donnelly,Mary Donnelly,Sandra Merscher-Gomez,Sandra Merscher-Gomez,Yoon Hee Chang,Yoon Hee Chang,Stefan Franz,Stefan Franz,Jacqueline Delfgaauw,Jacqueline Delfgaauw,Jer Ming Chang,Hoon Young Choi,Kirk N. Campbell,Kirk N. Campbell,Kwanghee Kim,Jochen Reiser,Jochen Reiser,Peter Mundel,Peter Mundel +19 more
TL;DR: It is shown that the beneficial effect of CsA on proteinuria is not dependent on NFAT inhibition in T cells, but rather results from the stabilization of the actin cytoskeleton in kidney podocytes, preserving the phosphorylation-dependent synaptopodin–14-3-3β interaction.
Journal ArticleDOI
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Jochen Reiser,Krishna R. Polu,Clemens C. Möller,Peter Kenlan,Mehmet M. Altintas,Changli Wei,Christian Faul,Stephanie Herbert,Ivan Villegas,Carmen Avila-Casado,Mary McGee,Hikaru Sugimoto,Dennis Brown,Raghu Kalluri,Peter Mundel,Paula Smith,David E. Clapham,Martin R. Pollak +17 more
TL;DR: It is shown that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm.
Journal ArticleDOI
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis
Changli Wei,Shafic El Hindi,Jing Li,Alessia Fornoni,Nelson Goes,Junichiro Sageshima,Dony Maiguel,S. Ananth Karumanchi,Hui-Kim Yap,Moin A. Saleem,Qing-Yin Zhang,Boris Nikolic,Abanti Chaudhuri,Pirouz Daftarian,Eduardo Salido,Armando Torres,Moro O. Salifu,Minnie M. Sarwal,Franz Schaefer,Christian Morath,Vedat Schwenger,Martin Zeier,Vineet Gupta,David M. Roth,Maria Pia Rastaldi,George W. Burke,Phillip Ruiz,Jochen Reiser +27 more
TL;DR: It is reported that serum soluble urokinase receptor (suPAR) is elevated in two-thirds of subjects with primary FSGS, but not in people with other glomerular diseases, and that a higher concentration of suPAR before transplantation underlies an increased risk for recurrence of FSGS after transplantation.