A
Atsuhiko T. Naito
Researcher at Toho University
Publications - 72
Citations - 3597
Atsuhiko T. Naito is an academic researcher from Toho University. The author has contributed to research in topics: QT interval & Wnt signaling pathway. The author has an hindex of 26, co-authored 72 publications receiving 2957 citations. Previous affiliations of Atsuhiko T. Naito include Chiba University & University of Tokyo.
Papers
More filters
Journal ArticleDOI
Developmental stage-specific biphasic roles of Wnt/β-catenin signaling in cardiomyogenesis and hematopoiesis
Atsuhiko T. Naito,Ichiro Shiojima,Hiroshi Akazawa,Kyoko Hidaka,Takayuki Morisaki,Akira Kikuchi,Issei Komuro +6 more
TL;DR: It is shown that Wnt/β-catenin signaling exhibits developmental stage-specific, biphasic, and antagonistic effects on cardiomyogenesis and hematopoiesis/vasculogenesis, depending on the stage of development.
Journal ArticleDOI
Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo
Tomomi Oyama,Toshio Nagai,Hiroshi Wada,Atsuhiko T. Naito,Katsuhisa Matsuura,Koji Iwanaga,Toshinao Takahashi,Motohiro Goto,Yoko Mikami,Noritaka Yasuda,Hiroshi Akazawa,Akiyoshi Uezumi,Shin'ichi Takeda,Issei Komuro +13 more
TL;DR: CSPs in injured heart differentiated into cardiomyocytes, endothelial cells, or smooth muscle cells, suggesting that CSPs are intrinsic cardiac stem cells and involved in the regeneration of diseased hearts.
Journal ArticleDOI
Angiogenesis and Cardiac Hypertrophy: Maintenance of Cardiac Function and Causative Roles in Heart Failure
TL;DR: Recent advances in understanding the regulatory mechanisms of coordinated myocardial growth and angiogenesis in the pathophysiology of cardiac hypertrophy and heart failure are summarized.
Journal ArticleDOI
Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes
Atsuhiko T. Naito,Tomokazu Sumida,Seitaro Nomura,Mei-Lan Liu,Tomoaki Higo,Akito Nakagawa,Katsuki Okada,Taku Sakai,Akihito Hashimoto,Yurina Hara,Ippei Shimizu,Weidong Zhu,Haruhiro Toko,Akemi Katada,Hiroshi Akazawa,Toru Oka,Jong-Kook Lee,Tohru Minamino,Toshio Nagai,Kenneth Walsh,Akira Kikuchi,Misako Matsumoto,Marina Botto,Ichiro Shiojima,Issei Komuro,Issei Komuro +25 more
TL;DR: It is reported that complement C1q activates canonical Wnt signaling and promotes aging-associated decline in tissue regeneration and suggest the unexpected role of complement C 1q in Wnt signal transduction and modulation of mammalian aging.
Journal ArticleDOI
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis
Weidong Zhu,Ichiro Shiojima,Yuzuru Ito,Zhi Li,Hiroyuki Ikeda,Masashi Yoshida,Atsuhiko T. Naito,Jun-ichiro Nishi,Hiroo Ueno,Akihiro Umezawa,Tohru Minamino,Toshio Nagai,Akira Kikuchi,Makoto Asashima,Makoto Asashima,Issei Komuro +15 more
TL;DR: IGBP-4 is therefore an inhibitor of the canonical Wnt signalling required for cardiogenesis and provides a molecular link between IGF signalling and WNT signalling.