J
Jong-Kook Lee
Researcher at Osaka University
Publications - 97
Citations - 3013
Jong-Kook Lee is an academic researcher from Osaka University. The author has contributed to research in topics: Embryonic stem cell & Superior cervical ganglion. The author has an hindex of 30, co-authored 95 publications receiving 2662 citations. Previous affiliations of Jong-Kook Lee include Japan Agency for Medical Research and Development & Nagoya University.
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Journal ArticleDOI
Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes
Atsuhiko T. Naito,Tomokazu Sumida,Seitaro Nomura,Mei-Lan Liu,Tomoaki Higo,Akito Nakagawa,Katsuki Okada,Taku Sakai,Akihito Hashimoto,Yurina Hara,Ippei Shimizu,Weidong Zhu,Haruhiro Toko,Akemi Katada,Hiroshi Akazawa,Toru Oka,Jong-Kook Lee,Tohru Minamino,Toshio Nagai,Kenneth Walsh,Akira Kikuchi,Misako Matsumoto,Marina Botto,Ichiro Shiojima,Issei Komuro,Issei Komuro +25 more
TL;DR: It is reported that complement C1q activates canonical Wnt signaling and promotes aging-associated decline in tissue regeneration and suggest the unexpected role of complement C 1q in Wnt signal transduction and modulation of mammalian aging.
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Sema3a maintains normal heart rhythm through sympathetic innervation patterning
Masaki Ieda,Hideaki Kanazawa,Kensuke Kimura,Fumiyuki Hattori,Yasuyo Ieda,Masahiko Taniguchi,Jong-Kook Lee,Keisuke Matsumura,Yuichi Tomita,Shunichiro Miyoshi,Kouji Shimoda,Shinji Makino,Motoaki Sano,Itsuo Kodama,Satoshi Ogawa,Keiichi Fukuda +15 more
TL;DR: It is shown that a neural chemorepellent, Sema3a, establishes cardiac sympathetic innervation patterning and is critical for heart rate control.
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Sinoatrial Node Dysfunction and Early Unexpected Death of Mice With a Defect of klotho Gene Expression
Kyosuke Takeshita,Toshihiko Fujimori,Yoko Kurotaki,Haruo Honjo,Hiroshi Tsujikawa,Kenji Yasui,Jong-Kook Lee,Kaichiro Kamiya,Kiyoyuki Kitaichi,Koji Yamamoto,Masafumi Ito,Takahisa Kondo,Shigeo Iino,Yasuya Inden,Makoto Hirai,Toyoaki Murohara,Itsuo Kodama,Yo-ichi Nabeshima +17 more
TL;DR: In the heart, klotho gene expression is essential for the sinoatrial node to function as a dependable pacemaker under conditions of stress.
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Chamber-specific differentiation of Nkx2.5-positive cardiac precursor cells from murine embryonic stem cells
Kyoko Hidaka,Jong-Kook Lee,Hoe Suk Kim,Chun Hwa Ihm,Akio Iio,Minetaro Ogawa,Shin-Ichi Nishikawa,Itsuo Kodama,Takayuki Morisaki +8 more
TL;DR: Results suggest that Nkx2.5(+) lineage cells possess the potential to differentiate into various cardiomyocyte cell types and that RA can modify the differentiation potential of Nk x 2.5/GFP(+)Cardiomyocytes at an early stage.
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Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period
Noriko Niwa,Kenji Yasui,Tobias Opthof,Haruki Takemura,Atsuya Shimizu,Mitsuru Horiba,Jong-Kook Lee,Haruo Honjo,Kaichiro Kamiya,Itsuo Kodama +9 more
TL;DR: Results indicate that Ca( v)3.2 underlies the functional T-type Ca2+ channels in the embryonic murine heart, and there is a subtype switching of transcripts from Ca(v) 3.2 to Ca(w)2.2 in the perinatal period.