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Bart Ghesquière
Researcher at Katholieke Universiteit Leuven
Publications - 125
Citations - 10991
Bart Ghesquière is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 45, co-authored 104 publications receiving 8073 citations. Previous affiliations of Bart Ghesquière include Ghent University & National Institutes of Health.
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Journal ArticleDOI
Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
Katrien De Bock,Maria Georgiadou,Sandra Schoors,Anna Kuchnio,Brian W. Wong,Anna Rita Cantelmo,Annelies Quaegebeur,Bart Ghesquière,Sandra Cauwenberghs,Guy Eelen,Li-Kun Phng,Inge Betz,Bieke Tembuyser,Katleen Brepoels,Jonathan Welti,Ilse Geudens,Inmaculada Segura,Bert Cruys,Franscesco Bifari,Ilaria Decimo,Raquel Blanco,Sabine Wyns,Jeroen Vangindertael,Susana Rocha,Russel T Collins,Sebastian Munck,Dirk Daelemans,Hiromi Imamura,Roland Devlieger,Mark H. Rider,Paul P. Van Veldhoven,Frans Schuit,Ramon Bartrons,Johan Hofkens,Peter Fraisl,Sucheta Telang,Ralph J. DeBerardinis,Luc Schoonjans,Stefan Vinckier,Jason Chesney,Holger Gerhardt,Holger Gerhardt,Mieke Dewerchin,Peter Carmeliet +43 more
TL;DR: It is shown that ECs relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the gly colytic activator PFKFB3 in ECs impaired vessel formation.
Journal ArticleDOI
A roadmap for interpreting 13 C metabolite labeling patterns from cells
Joerg Martin Buescher,Maciek R. Antoniewicz,Laszlo G. Boros,Shawn C. Burgess,Henri Brunengraber,Clary B. Clish,Ralph J. DeBerardinis,Olivier Feron,Christian Frezza,Bart Ghesquière,Eyal Gottlieb,Karsten Hiller,Russell G. Jones,Jurre J. Kamphorst,Richard G. Kibbey,Alec C. Kimmelman,Jason W. Locasale,Sophia Y. Lunt,Oliver D. K. Maddocks,Craig R. Malloy,Christian M. Metallo,Emmanuelle J. Meuillet,Joshua Munger,Katharina Nöh,Joshua D. Rabinowitz,Markus Ralser,Markus Ralser,Uwe Sauer,Gregory Stephanopoulos,Julie St-Pierre,Daniel A. Tennant,Christoph Wittmann,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Alexei Vazquez,Karen H. Vousden,Jamey D. Young,Nicola Zamboni,Sarah-Maria Fendt +38 more
TL;DR: Key issues in interpreting (13)C metabolite labeling patterns are reviewed, with the goal of drawing accurate conclusions from steady state and dynamic stable isotopic tracer experiments.
Journal ArticleDOI
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
Bernard Thienpont,Jessica Steinbacher,Hui Zhao,Flora D’Anna,Anna Kuchnio,Athanasios Ploumakis,Bart Ghesquière,Laurien Van Dyck,Bram Boeckx,Luc Schoonjans,Els Hermans,Frédéric Amant,Vessela N. Kristensen,Kian Peng Koh,Massimiliano Mazzone,Mathew L. Coleman,Thomas Carell,Peter Carmeliet,Diether Lambrechts +18 more
TL;DR: Tumour hypoxia acts as a novel regulator of DNA methylation in tumour suppressor genes by reducing the activity of oxygen-dependent ten-eleven translocation enzymes in human and mouse cells.
Journal ArticleDOI
Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Sandra Schoors,Ulrike Bruning,Rindert Missiaen,Karla C. S. Queiroz,Gitte Borgers,Ilaria Elia,Annalisa Zecchin,Anna Rita Cantelmo,Stefan Christen,Jermaine Goveia,Ward Heggermont,Lucica Godde,Stefan Vinckier,Paul P. Van Veldhoven,Guy Eelen,Luc Schoonjans,Holger Gerhardt,Mieke Dewerchin,Myriam Baes,Katrien De Bock,Bart Ghesquière,Sophia Y. Lunt,Sarah-Maria Fendt,Peter Carmeliet +23 more
TL;DR: It is reported that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not migration, of human and murine endothelial cells.
Journal ArticleDOI
Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy
Anna Rita Cantelmo,Lena Christin Conradi,Aleksandra Brajic,Jermaine Goveia,Joanna Kalucka,Andreas Pircher,Pallavi Chaturvedi,Johanna Hol,Bernard Thienpont,Laure Anne Teuwen,Sandra Schoors,Bram Boeckx,Joris Vriens,Anna Kuchnio,Koen Veys,Bert Cruys,Lise Finotto,Lucas Treps,Tor Espen Stav-Noraas,Francesco Bifari,Peter C. Stapor,Ilaria Decimo,Kim R. Kampen,Katrien De Bock,Guttorm Haraldsen,Luc Schoonjans,Ton J. Rabelink,Guy Eelen,Bart Ghesquière,Jalees Rehman,Diether Lambrechts,Asrar B. Malik,Mieke Dewerchin,Peter Carmeliet +33 more
TL;DR: It is shown that tumor endothelial cells (ECs) have a hyper-glycolytic metabolism, shunting intermediates to nucleotide synthesis, which reduces cancer cell invasion, intravasation, and metastasis by normalizing tumor vessels by PFKFB3-blockade treatment, which improved vessel maturation and perfusion.