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Aurelio Galli
Researcher at University of Alabama at Birmingham
Publications - 113
Citations - 9569
Aurelio Galli is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Dopamine transporter & Dopamine. The author has an hindex of 53, co-authored 110 publications receiving 8769 citations. Previous affiliations of Aurelio Galli include University of Texas at San Antonio & Mario Negri Institute for Pharmacological Research.
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Journal ArticleDOI
Mechanisms of neurotransmitter release by amphetamines: a review.
TL;DR: Current issues on the two apparent primary mechanisms--the redistribution of catecholamines from synaptic vesicles to the cytosol, and induction of reverse transport of transmitter through plasma membrane uptake carriers are reviewed.
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Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism.
Christine Saunders,Jasmine V. Ferrer,Lei Shi,Jiayun Chen,Gerald A. Merrill,Maria E. Lamb,L. M. Fredrik Leeb-Lundberg,Lucia Carvelli,Jonathan A. Javitch,Aurelio Galli +9 more
TL;DR: Evidence is presented that DAT substrates, including AMPH and DA, cause internalization of human DAT, thereby reducing transport capacity, and acute application of AMPH would reduce DA uptake not only by direct competition for uptake, but also by reducing the available cell-surface DAT.
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Protein Kinase C Activation Regulates Human Serotonin Transporters in HEK-293 Cells via Altered Cell Surface Expression
Yan Qian,Aurelio Galli,Sammanda Ramamoorthy,Stefania Risso,Louis J. DeFelice,Randy D. Blakely +5 more
TL;DR: Data indicate that altered surface abundance, rather than reduced catalytic transport efficiency, mediates acute PKC-dependent modulation of 5-HT uptake, and that activity reductions are paralleled by a staurosporine-sensitive loss of surface SERT protein.
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Amphetamine induces dopamine efflux through a dopamine transporter channel
Kristopher M. Kahlig,Francesca Binda,Habibeh Khoshbouei,Randy D. Blakely,Douglas G. McMahon,Jonathan A. Javitch,Aurelio Galli +6 more
TL;DR: It is reported that AMPH causes DAT-mediated DA efflux by two independent mechanisms: a slow process consistent with an exchange mechanism and a process that results in rapid (millisecond) bursts ofDA efflux through a channel-like mode of DAT.
Journal ArticleDOI
Mitogen-Activated Protein Kinase Regulates Dopamine Transporter Surface Expression and Dopamine Transport Capacity
Jose A. Morón,Irina O. Zakharova,Jasmine V. Ferrer,Gerald A. Merrill,Bruce T. Hope,Eileen M. Lafer,Zhicheng Lin,Jia Bei Wang,Jonathan A. Javitch,Aurelio Galli,Toni S. Shippenberg +10 more
TL;DR: An involvement of the MAPK cascade in regulating DAT transport capacity in striatum is demonstrated and that inhibition of this cascade decreases DAT cell surface expression in HEK 293 cells is highlighted, highlighting the potential role of MAPK as a presynaptic mechanism that regulates DA signaling.