Jose A. Morón

TL;DR: Comparing the effects of inhibitors selective for the three monoamine transporters with those of a nonspecific inhibitor, cocaine, on uptake of 3H-dopamine into synaptosomes from frontal cortex, caudate nucleus, and nucleus accumbens from wild-type, NET, and dopamine transporter (DAT) knock-out mice suggests that dopamine in this region is normally cleared by the somewhat promiscuous NET.

TL;DR: An involvement of the MAPK cascade in regulating DAT transport capacity in striatum is demonstrated and that inhibition of this cascade decreases DAT cell surface expression in HEK 293 cells is highlighted, highlighting the potential role of MAPK as a presynaptic mechanism that regulates DA signaling.

TL;DR: Inhibition of phosphatidylinositol (PI) 3‐kinase with LY294002 induces internalization of the human DAT (hDAT), thereby reducing transport capacity, and implicate DAT trafficking in the hormonal regulation of dopaminergic signaling, and suggest that a state of chronic hypoinsulinemia, such as in diabetes, may alter synaptic DA signaling by reducing the available cell surface DATs.

TL;DR: Cocaine-induced increases in cell surface expression of DAT and associated changes in DA clearance represent a novel mechanism that may play a role in its addictive properties.

TL;DR: HDAT cell-surface expression is regulated by the insulin signaling pathway and that Akt plays a key role in the hormonal modulation of AMPH-induced hDAT trafficking and in the regulation of basal hD AT cell- surface expression.