L
L. M. Fredrik Leeb-Lundberg
Researcher at Lund University
Publications - 58
Citations - 4610
L. M. Fredrik Leeb-Lundberg is an academic researcher from Lund University. The author has contributed to research in topics: Receptor & Kinin. The author has an hindex of 31, co-authored 57 publications receiving 4303 citations. Previous affiliations of L. M. Fredrik Leeb-Lundberg include Howard Hughes Medical Institute & University of Texas System.
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Journal ArticleDOI
International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences
L. M. Fredrik Leeb-Lundberg,François Marceau,Werner Müller-Esterl,Douglas J. Pettibone,Bruce L. Zuraw +4 more
TL;DR: This review is a comprehensive presentation of the current understanding of B1 and B2 receptors in terms of molecular and cell biology, physiology, pharmacology, and involvement in human disease and drug development.
Journal ArticleDOI
Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism.
Christine Saunders,Jasmine V. Ferrer,Lei Shi,Jiayun Chen,Gerald A. Merrill,Maria E. Lamb,L. M. Fredrik Leeb-Lundberg,Lucia Carvelli,Jonathan A. Javitch,Aurelio Galli +9 more
TL;DR: Evidence is presented that DAT substrates, including AMPH and DA, cause internalization of human DAT, thereby reducing transport capacity, and acute application of AMPH would reduce DA uptake not only by direct competition for uptake, but also by reducing the available cell-surface DAT.
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Deletion of the G Protein-Coupled Receptor 30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-Stimulated Insulin Release in Female Mice
Ulrika E.A. Mårtensson,S Albert Salehi,Sara H Windahl,Maria F. Gomez,Karl Swärd,Joanna Daszkiewicz-Nilsson,Anna Wendt,Niklas Andersson,Per Hellstrand,Per-Olof Grände,Christer Owman,Clifford J. Rosen,Martin L. Adamo,Ingmar Lundquist,Patrik Rorsman,Bengt-Olof Nilsson,Claes Ohlsson,Björn Olde,L. M. Fredrik Leeb-Lundberg +18 more
TL;DR: The findings show that GPR30 is important for several metabolic functions in female mice, including estradiol-stimulated insulin release, which is associated with decreased insulin expression and release in vivo and in vitro in isolated pancreatic islets.
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Bradykinin Sequesters B2 Bradykinin Receptors and the Receptor-coupled Gα Subunits Gαq and Gαiin Caveolae in DDT1 MF-2 Smooth Muscle Cells
TL;DR: It is shown that the vasoactive peptide agonist bradykinin when bound to B2 BK receptors on DDT1 MF-2 smooth muscle cells promotes the recruitment and sequestration of the occupied receptors and the receptor-coupled G-protein α subunits Gαq and Gαi in caveolae.
Journal ArticleDOI
Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes
Knut Kotarsky,Åke Boketoft,Jesper Bristulf,Niclas E. Nilsson,Åke Norberg,Stefan R. Hansson,Christer Owman,Rannar Sillard,L. M. Fredrik Leeb-Lundberg,Björn Olde +9 more
TL;DR: The ligand binding, activation, and tissue distribution of the orphan G protein-coupled receptor (GPCR) GPR92 were studied and it was found that it is the most abundant GPCR activated by LPA found in the small intestinal intraepithelial CD8+ cytotoxic T cells.