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Aurora O'Brate
Researcher at Cornell University
Publications - 28
Citations - 1689
Aurora O'Brate is an academic researcher from Cornell University. The author has contributed to research in topics: Tubulin & Microtubule. The author has an hindex of 18, co-authored 28 publications receiving 1606 citations. Previous affiliations of Aurora O'Brate include Emory University & University of California, San Diego.
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Journal ArticleDOI
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.
Donald E. Pryor,Aurora O'Brate,Geoffrey Bilcer,J. Fernando Díaz,Yuefang Wang,Yong Wang,Mikio Kabaki,M. Katherine Jung,José Manuel Andreu,Arun K. Ghosh,and Paraskevi Giannakakou,Ernest Hamel +11 more
TL;DR: It is found that laulimalide, while as active as paclitaxel, epothilone A, and eleutherobin in promoting the assembly of cold-stable microtubules, was unable to inhibit the binding of radiolabeled pac litaxel or of 7-O-[N-(2,7-difluoro-4'-fluoresceincarbonyl)-L-alanyl]paclitaxe, a fluorescent paclitxel
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The importance of p53 location: nuclear or cytoplasmic zip code?
TL;DR: This review aims to present the most recent data on how the activity of p53 is regulated by its location.
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Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics.
Paraskevi Giannakakou,Michel Y. Nakano,Kyriacos C. Nicolaou,Aurora O'Brate,Jian Yu,Mikhail V. Blagosklonny,Urs F. Greber,Tito Fojo +7 more
TL;DR: It is proposed that suppression of MT dynamics by low concentrations of MTCs enhances MT-dependent trafficking toward the minus ends of MTs and facilitates nuclear targeting.
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Chemistry and Biology of Diazonamide A: Second Total Synthesis and Biological Investigations
Kyriacos C. Nicolaou,Junliang Hao,Mali V. Reddy,Paraselli Bheema Rao,Gerasimos A. Rassias,Scott A. Snyder,Xianhai Huang,David Y.-K. Chen,William E. Brenzovich,Nicolas Giuseppone,Aurora O'Brate,Paraskevi Giannakakou +11 more
TL;DR: This article details the second total synthesis of diazonamide A through a sequence entirely distinct from that employed in the first campaign, one whose success required the development of several special strategies and tactics.
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Interaction of Epothilone Analogs with the Paclitaxel Binding Site: Relationship between Binding Affinity, Microtubule Stabilization, and Cytotoxicity
Rubén M. Buey,J. Fernando Díaz,José Manuel Andreu,Aurora O'Brate,Paraskevi Giannakakou,Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Pradip K. Sasmal,Pradip K. Sasmal,Andreas Ritzén,Andreas Ritzén,Kenji Namoto,Kenji Namoto +12 more
TL;DR: The correlation between binding, microtubule stabilization, and cytotoxicity of the compounds has been determined, and the binding constants correlate well with IC(50) values, demonstrating that affinity measurements are a useful tool for drug design.