A
Azad Kumar
Researcher at National Institutes of Health
Publications - 34
Citations - 3163
Azad Kumar is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Potentiometric sensor & Medicine. The author has an hindex of 21, co-authored 30 publications receiving 2611 citations. Previous affiliations of Azad Kumar include Max Planck Society & Indian Institute of Technology Roorkee.
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Journal ArticleDOI
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
Jason S. McLellan,Man Chen,M. Gordon Joyce,Mallika Sastry,Guillaume Stewart-Jones,Yongping Yang,Baoshan Zhang,Lei Chen,Sanjay Srivatsan,Anqi Zheng,Tongqing Zhou,Kevin W. Graepel,Azad Kumar,Syed M. Moin,Jeffrey C. Boyington,Gwo-Yu Chuang,Cinque Soto,Ulrich Baxa,Arjen Q. Bakker,Hergen Spits,Tim Beaumont,Zizheng Zheng,Ningshao Xia,Sung Youl Ko,John Paul Todd,Srinivas S. Rao,Barney S. Graham,Peter D. Kwong +27 more
TL;DR: A viral antigen is sought that provides greater protection than currently available vaccines and focused on antigenic site Ø, a metastable site specific to the prefusion state of the RSV fusion (F) glycoprotein, as this site is targeted by extremely potent RSV-neutralizing antibodies.
Journal ArticleDOI
Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody
Jason S. McLellan,Man Chen,Sherman Leung,Kevin W. Graepel,Xiulian Du,Yongping Yang,Tongqing Zhou,Ulrich Baxa,Etsuko Yasuda,Tim Beaumont,Azad Kumar,Kayvon Modjarrad,Zizheng Zheng,Min Zhao,Ningshao Xia,Peter D. Kwong,Barney S. Graham +16 more
TL;DR: Preference-specific antibodies that were substantially more potent than the prophylactic antibody palivizumab were identified, which should enable design of improved vaccine antigens and define new targets for passive prevention of RSV-induced disease.
Journal ArticleDOI
Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera
Joan O. Ngwuta,Man Chen,Kayvon Modjarrad,Kayvon Modjarrad,M. Gordon Joyce,Masaru Kanekiyo,Azad Kumar,Hadi M. Yassine,Syed M. Moin,April M. Killikelly,Gwo-Yu Chuang,Aliaksandr Druz,Ivelin S. Georgiev,Emily J. Rundlet,Mallika Sastry,Guillaume Stewart-Jones,Yongping Yang,Baoshan Zhang,Martha Nason,Cristina Capella,Mark E. Peeples,Julie E. Ledgerwood,Jason S. McLellan,Jason S. McLellan,Peter D. Kwong,Barney S. Graham +25 more
TL;DR: The results indicate that RSV NT activity in human sera is primarily derived from pre-F–specific antibodies, and therefore, inducing or boosting NT activity by vaccination will be facilitated by using pre- F antigens that preserve site Ø.
Journal ArticleDOI
Preparation of ethambutol/copper(II) complex and fabrication of PVC based membrane potentiometric sensor for copper
TL;DR: The sensor works well in the pH range 2.1-6.3 and could be satisfactorily used in presence of 40% (v/v) methanol, ethanol and acetone and is selective for copper over a large number of cations with slight interference from Na(+) and Co(2+) if present at a level 1.5x10(-5) M.
Journal ArticleDOI
Metallo-tetraazaporphyrin based anion sensors: regulation of sensor characteristics through central metal ion coordination
TL;DR: In this paper, the iron-cobalt complexes of 2,3,7,8,12,13,17,18-octakis(benzylthio)-5,10,15,20-tetraazaporphyrin (OBTAP) were synthesized and incorporated into PVC matrix as ionophores to fabricate anion selective membrane electrodes that exhibit selective potentiometric response to azide and nitrite ions, respectively.