A
Anqi Zheng
Researcher at National Institutes of Health
Publications - 29
Citations - 3365
Anqi Zheng is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 11 publications receiving 2669 citations. Previous affiliations of Anqi Zheng include Vaccine Research Center.
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Journal ArticleDOI
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Hua-Xin Liao,Rebecca M. Lynch,Tongqing Zhou,Feng Gao,Feng Gao,S. Munir Alam,S. Munir Alam,Scott D. Boyd,Andrew Fire,Krishna M. Roskin,Chaim A. Schramm,Zhenhai Zhang,Jiang Zhu,Lawrence Shapiro,Lawrence Shapiro,Nisc Comparative Sequencing Program,James C. Mullikin,Sandrasegaram Gnanakaran,Peter T. Hraber,Kevin Wiehe,Kevin Wiehe,Garnett Kelsoe,Garnett Kelsoe,Guang Yang,Guang Yang,Shi-Mao Xia,Shi-Mao Xia,David C. Montefiori,David C. Montefiori,Robert Parks,Robert Parks,Krissey E. Lloyd,Krissey E. Lloyd,Richard M. Scearce,Richard M. Scearce,Kelly A. Soderberg,Kelly A. Soderberg,Myron S. Cohen,Gift Kamanga,Mark K. Louder,Lillian Tran,Yue Chen,Yue Chen,Fangping Cai,Fangping Cai,Sheri Chen,Sheri Chen,Stephanie Moquin,Xiulian Du,M. Gordon Joyce,Sanjay Srivatsan,Baoshan Zhang,Anqi Zheng,George M. Shaw,Beatrice H. Hahn,Thomas B. Kepler,Bette T. Korber,Peter D. Kwong,John R. Mascola,Barton F. Haynes,Barton F. Haynes +60 more
TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.
Journal ArticleDOI
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
Jason S. McLellan,Man Chen,M. Gordon Joyce,Mallika Sastry,Guillaume Stewart-Jones,Yongping Yang,Baoshan Zhang,Lei Chen,Sanjay Srivatsan,Anqi Zheng,Tongqing Zhou,Kevin W. Graepel,Azad Kumar,Syed M. Moin,Jeffrey C. Boyington,Gwo-Yu Chuang,Cinque Soto,Ulrich Baxa,Arjen Q. Bakker,Hergen Spits,Tim Beaumont,Zizheng Zheng,Ningshao Xia,Sung Youl Ko,John Paul Todd,Srinivas S. Rao,Barney S. Graham,Peter D. Kwong +27 more
TL;DR: A viral antigen is sought that provides greater protection than currently available vaccines and focused on antigenic site Ø, a metastable site specific to the prefusion state of the RSV fusion (F) glycoprotein, as this site is targeted by extremely potent RSV-neutralizing antibodies.
Journal ArticleDOI
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Tongqing Zhou,Jiang Zhu,Xueling Wu,Stephanie Moquin,Baoshan Zhang,Priyamvada Acharya,Ivelin S. Georgiev,Han Altae-Tran,Gwo-Yu Chuang,M. Gordon Joyce,Young Do Kwon,Nancy S. Longo,Mark K. Louder,Timothy S. Luongo,Krisha McKee,Chaim A. Schramm,Jeff Skinner,Yongping Yang,Zhongjia Yang,Zhenhai Zhang,Anqi Zheng,Mattia Bonsignori,Barton F. Haynes,Johannes F. Scheid,Michel C. Nussenzweig,Michel C. Nussenzweig,Melissa Simek,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,James C. Mullikin,Mark Connors,Lawrence Shapiro,Lawrence Shapiro,Gary J. Nabel,John R. Mascola,Peter D. Kwong +36 more
TL;DR: Developmental similarities in multiple donors thus reveal the generation of VRC01-class antibodies to be reproducible in principle, thereby providing a framework for attempts to elicit similar antibodies in the general population.
Journal ArticleDOI
Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.
Jinghe Huang,Byong H. Kang,Elise Ishida,Tongqing Zhou,Trevor Griesman,Zizhang Sheng,Fan Wu,Nicole A. Doria-Rose,Baoshan Zhang,Krisha McKee,Sijy O'Dell,Gwo-Yu Chuang,Aliaksandr Druz,Ivelin S. Georgiev,Chaim A. Schramm,Anqi Zheng,M. Gordon Joyce,Mangaiarkarasi Asokan,Amy Ransier,Sam Darko,Stephen A. Migueles,Robert T. Bailer,Mark K. Louder,S. Munir Alam,Robert Parks,Garnett Kelsoe,Tarra Von Holle,Barton F. Haynes,Daniel C. Douek,Vanessa M. Hirsch,Michael S. Seaman,Lawrence Shapiro,Lawrence Shapiro,John R. Mascola,Peter D. Kwong,Mark Connors +35 more
TL;DR: A CD4-binding site (CD4bs) antibody, named N6, is reported that potently neutralized 98% of HIV-1 isolates, including 16 of 20 that were resistant to other members of its class.
Journal ArticleDOI
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
Mattia Bonsignori,Tongqing Zhou,Zizhang Sheng,Lei Chen,Feng Gao,M. Gordon Joyce,Gabriel Ozorowski,Gwo-Yu Chuang,Chaim A. Schramm,Kevin Wiehe,S. Munir Alam,Todd Bradley,Morgan A. Gladden,Kwan-Ki Hwang,Sheelah Iyengar,Amit Kumar,Xiaozhi Lu,Kan Luo,Michael C. Mangiapani,Robert Parks,Hongshuo Song,Priyamvada Acharya,Robert T. Bailer,Allen Cao,Aliaksandr Druz,Ivelin S. Georgiev,Young Do Kwon,Mark K. Louder,Baoshan Zhang,Anqi Zheng,Brenna J. Hill,Rui Kong,Cinque Soto,James C. Mullikin,Daniel C. Douek,David C. Montefiori,M. A. Moody,George M. Shaw,Beatrice H. Hahn,Garnett Kelsoe,Peter T. Hraber,Bette T. Korber,Scott D. Boyd,Andrew Fire,Thomas B. Kepler,Lawrence Shapiro,Lawrence Shapiro,Andrew B. Ward,John R. Mascola,Hua-Xin Liao,Peter D. Kwong,Barton F. Haynes +51 more
TL;DR: The development of a VH1-46-derived antibody lineage that matured to neutralize 90% of HIV-1 isolates is defined with longitudinal sampling from time-of-infection to suggest a vaccination strategy for inducing both lineages.