J. Appl. Cryst.の発刊に際して

The Pharmacological Basis of Therapeutics A Textbook of Pharmacology, Toxicology and Therapeutics for Physicians and Medical Students. By Prof. Louis Goodman and Prof. Alfred Gilman. Pp. xiii + 1383. (New York: The Macmillan Company, 1941.) 50s. net.

The Pharmacological Basis of Therapeutics

There is a special reason for reviewing this book at this time: it is the 50th edition of a compendium that is known and used frequently in most chemical and physical laboratories in many parts of the world. Surely, a publication that has been published for 56 years, withstanding the vagaries of science in this century, must have had something to offer. There is another reason: while the book is a standard fixture in most chemical and physical laboratories, including those in medical centers, it is not as frequently seen in the laboratories of physician's offices (those either in solo or group practice). I believe that the Handbook can be useful in those laboratories. One of the reasons, among others, is that the various basic items of information it offers may be helpful in new tests, either physical or chemical, which are continuously being published. The basic information may relate

Handbook of Chemistry and Physics

Chem. Pharm. Bull.(オピニオン)

We report a study of self-assembled beta-pleated sheets in B. mori silk fibroin films using thermal analysis and infrared spectroscopy. B. mori silk fibroin may stand as an exemplar of fibrous proteins containing crystalline beta-sheets. Materials were prepared from concentrated solutions (2−5 wt % fibroin in water) and then dried to achieve a less ordered state without beta-sheets. Crystallization of beta-pleated sheets was effected either by heating the films above the glass transition temperature (Tg) and holding isothermally or by exposure to methanol. The fractions of secondary structural components including random coils, alpha-helices, beta-pleated sheets, turns, and side chains were evaluated using Fourier self-deconvolution (FSD) of the infrared absorbance spectra. The silk fibroin films were studied thermally using temperature-modulated differential scanning calorimetry (TMDSC) to obtain the reversing heat capacity. The increment of the reversing heat capacity ΔCp0(Tg) at the glass transition fo...

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Determining Beta Sheet Crystallinity in Fibrous Proteins by Thermal Analysis and Infrared Spectroscopy

In the title compound, C29H22Br2O3, the dihedral angles between the mean planes of the benzene rings within each biphenyl group are 26.7 (8) and 30.9 (8)°. The mean planes of the terminal and inner benzene rings of the biphenyl groups bonded through a propan-1-one group in the V-shaped mol­ecule are oriented at angles of 66.1 (7) and 60.0 (8)°, respectively. The two Br atoms are opposite the propen-1-one group. Weak inter­molecular C—H⋯O and C—H⋯π inter­actions are observed in the crystal structure.

https://journals.iucr.org/e/issues/2012/02/00/tk5043/tk5043.pdf

1,3-Bis(biphenyl-4-yl)-2,2-dibromo-3-oxopropyl acetate

In the title compound, C17H16N2O3·3H2O, the dihedral angle between the mean planes of the benzene and benzimidazole systems is 26.2 (3)°. These groups are slightly twisted around the eth­oxy­methane unit [C—C—O—C torsion angle = 177.64 (15)°]. The crystal packing is stabilized by N—H⋯O, O—H⋯N and O—H⋯O hydrogen-bond inter­actions involving the water mol­ecules. Weak π–π stacking inter­actions [centroid–centroid distances = 3.7943 (7), 3.6919 (13) and 3.7533 (14) A] contribute to the mol­ecular stability.

https://journals.iucr.org/e/issues/2010/08/00/fl2307/fl2307.pdf

4-(1H-Benzimidazol-2-ylmeth-oxy)-3-eth-oxy-benzaldehyde trihydrate.

The title compound, C13H18O3, crystallizes with three independent molecules in the asymmetric unit. In the crystal structure, two of the molecules form a hydrogen-bonded dimer, while the third forms a centrosymmetric hydrogen-bonded dimer with its symmetry-equivalent molecule. In each independent molecule, there is an intramolecular O-H (.) (.) (.) O hydrogen bond.

/pdf/2-hydroxy-3-5-diisopropylbenzoic-acid-14nvbbjwl2.pdf

2-hydroxy-3,5-diisopropylbenzoic acid

The asymmetric unit of the title salt solvate, 2C(11)H(15)ClNO(+)center dot 2C(6)H(2)N(3)O(7)(-)center dot C(2)H(6)OS, contains two crystallographically independent 4-(4-chlorophenyl)-4-hydroxypiperidinium cations, two picrate anions and a dimethyl sulfoxide solvent molecule. In each cation, the piperidinium ring adopts a chair conformation. In the crystal structure, the cations, anions and solvent molecules are connected by intermolecular O-H center dot center dot center dot O, N-H center dot center dot center dot O and C-H center dot center dot center dot O hydrogen bonds, forming a three-dimensional network.

Bis4-(4-chlorophenyl)-4-hydroxypiperidinium] dipicrate dimethyl sulfoxide solvate

In the title compound, C13H13NO4, the N—C(=O) bond length of 1.354 (2) A is indicative of amide-type resonance. The dihedral angle between the mean planes of the benzene ring and oxo­amine group is 36.4 (3)°, while the mean plane of the 2-methyl­idene group is inclined by 84.2 (01)° from that of the oxo­amine group. In the crystal, classical O—H⋯O hydrogen bonds formed by the carb­oxy­lic acid groups and weak N—H⋯O weak inter­actions formed by the amide groups and supported by weak C—H⋯O inter­actions between the 2-methyl­idene, phenyl and acetyl groups with the carb­oxy­lic acid, oxo­amine and acetyl O atoms, together link the mol­ecules into dimeric chains along [010]. The O—H⋯O hydrogen bonds form R22(8) graph-set motifs.

https://journals.iucr.org/e/issues/2014/07/00/zl2589/zl2589.pdf

Badiadka Narayana

Papers

1,3-Bis(biphenyl-4-yl)-2,2-dibromo-3-oxopropyl acetate

4-(1H-Benzimidazol-2-ylmeth-oxy)-3-eth-oxy-benzaldehyde trihydrate.

2-hydroxy-3,5-diisopropylbenzoic acid

Bis4-(4-chlorophenyl)-4-hydroxypiperidinium] dipicrate dimethyl sulfoxide solvate

4-[(4-Acetylphenyl)amino]-2-methylidene-4-oxobutanoic acid

Badiadka Narayana

Papers

1,3-Bis(biphenyl-4-yl)-2,2-dibromo-3-oxopropyl acetate

4-(1H-Benzimidazol-2-ylmeth-oxy)-3-eth-oxy-benzaldehyde trihydrate.

2-hydroxy-3,5-diisopropylbenzoic acid

Bis4-(4-chlorophenyl)-4-hydroxypiperidinium] dipicrate dimethyl sulfoxide solvate

4-[(4-Acetyl­phen­yl)amino]-2-methyl­idene-4-oxo­butanoic acid

4-[(4-Acetylphenyl)amino]-2-methylidene-4-oxobutanoic acid