J. Appl. Cryst.の発刊に際して

The Pharmacological Basis of Therapeutics A Textbook of Pharmacology, Toxicology and Therapeutics for Physicians and Medical Students. By Prof. Louis Goodman and Prof. Alfred Gilman. Pp. xiii + 1383. (New York: The Macmillan Company, 1941.) 50s. net.

The Pharmacological Basis of Therapeutics

There is a special reason for reviewing this book at this time: it is the 50th edition of a compendium that is known and used frequently in most chemical and physical laboratories in many parts of the world. Surely, a publication that has been published for 56 years, withstanding the vagaries of science in this century, must have had something to offer. There is another reason: while the book is a standard fixture in most chemical and physical laboratories, including those in medical centers, it is not as frequently seen in the laboratories of physician's offices (those either in solo or group practice). I believe that the Handbook can be useful in those laboratories. One of the reasons, among others, is that the various basic items of information it offers may be helpful in new tests, either physical or chemical, which are continuously being published. The basic information may relate

Handbook of Chemistry and Physics

Chem. Pharm. Bull.(オピニオン)

We report a study of self-assembled beta-pleated sheets in B. mori silk fibroin films using thermal analysis and infrared spectroscopy. B. mori silk fibroin may stand as an exemplar of fibrous proteins containing crystalline beta-sheets. Materials were prepared from concentrated solutions (2−5 wt % fibroin in water) and then dried to achieve a less ordered state without beta-sheets. Crystallization of beta-pleated sheets was effected either by heating the films above the glass transition temperature (Tg) and holding isothermally or by exposure to methanol. The fractions of secondary structural components including random coils, alpha-helices, beta-pleated sheets, turns, and side chains were evaluated using Fourier self-deconvolution (FSD) of the infrared absorbance spectra. The silk fibroin films were studied thermally using temperature-modulated differential scanning calorimetry (TMDSC) to obtain the reversing heat capacity. The increment of the reversing heat capacity ΔCp0(Tg) at the glass transition fo...

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Determining Beta Sheet Crystallinity in Fibrous Proteins by Thermal Analysis and Infrared Spectroscopy

An accurate, selective and rapid complexotitrimetric method is described for the determination of CuII in the presence of other metal ions. The method is based on the selective complexing ability of cysteine with CuII. Copper in the aliquot is initially complexed by the addition of ethylenediaminetetraacetic acid (H4edta) solution and the excess H4edta is titrated against Pb(NO3)2 solution (pH 5.0–6.0) using hexamine and Xylenol Orange. A known excess of DL-cysteine in water is then added to release the H4edta from the CuII—H4edta complex. This is subsequently titrated against Pb(NO3)2 to the same sharp end-point. The amount of H4edta released from the complex is thus equivalent to the amount of CuII in the solution. The method works well for Cu in various alloys and metal complexes. Reproducible and accurate results are obtained in the concentration range 3–32 mg per aliquot with a relative error of <0.6% and a standard deviation of <0.04%. The effect of various cations and anions is also studied. The interference of a number of ions, such as ZrIV, SnIV, TIIII, HgII and PdII can be overcome by the use of suitable secondary masking agents.

Complexometric determination of copper in isolation, alloys and complexes using DL-cysteine as a selective masking agent

In the title compound, C20H15ClFNO, the dihedral angles between the mean planes of the acetamide group and the chloro­fluoro-substituted benzene ring and the two phenyl rings are 10.8 (8), 81.9 (7) and 85.8 (5)°, respectively. The crystal packing is stabilized by N—H⋯O hydrogen bonds and weak C—H⋯O inter­molecular inter­actions, forming infinite chains along the c axis.

https://journals.iucr.org/e/issues/2011/10/00/ya2145/ya2145.pdf

N-(3-Chloro-4-fluoro­phen­yl)-2,2-diphenyl­acetamide

Foi desenvolvido um metodo simples, rapido e sensivel para a determinacao de periodato em amostras de agua de rio e em solucao. O metodo e baseado na reacao do periodato com iodeto em meio acido, com liberacao de iodo. O iodo liberado diminui a intensidade da cor violeta do azure B, medida em 644 nm. O decaimento da absorbância e diretamente proporcional a concentracao de periodato e obedece a lei de Beer na faixa de 0,2 - 5,5 µg mL-1. A absortividade molar, a sensibilidade de Sandell e os limites de deteccao e de quantificacao encontrados foram 1,09x105 L mol-1 cm-1, 1,75x10-3 µg cm-2, 0,07 µg mL-1 and 0,20 µg mL-1, respectivamente. As condicoes otimas de reacao e os parâmetros analiticos foram avaliados. O efeito de ions interferentes e descrito. O metodo proposto foi aplicado com sucesso na determinacao de periodato em amostras de aguas de rio e em solucao.

/pdf/a-facile-spectrophotometric-method-for-the-determination-of-1g9g2idukp.pdf

A facile spectrophotometric method for the determination of periodate using azure B

A complexo-titrimetric method for the determination of mercury(II) in the presence of other metal ions is described, based on the selective masking ability of sulphite ion towards Hg(II). Mercury in a given sample solution is initially complexed with a known excess of EDTA and the surplus EDTA titrated with zinc sulphate solution at pH 5.0–6.0 (hexamine), using xylenol orange (or methylthymol blue) as indicator. An excess of solid sodium sulphite is then added to decompose the Hg(II)-EDTA complex and the released EDTA is titrated with standard zinc sulphate solution. Reproducible and accurate results are obtained for 9.9–99 mg Hg with relative errors < 0.35% and standard deviations < 0.05 mg. The effects of various cations and anions are studied.

Selective complexometric determination of mercury with sulphite as indirect masking reagent

Silk fibroin (SF) microparticles were fabricated by blending of SF solution with hydroxyl propyl methyl cellulose (HPMC), and the SF/HPMC blend films were prepared using simple solvent evaporation 

Badiadka Narayana

Papers

Complexometric determination of copper in isolation, alloys and complexes using DL-cysteine as a selective masking agent

N-(3-Chloro-4-fluorophenyl)-2,2-diphenylacetamide

A facile spectrophotometric method for the determination of periodate using azure B

Selective complexometric determination of mercury with sulphite as indirect masking reagent

Facile fabrication of silk fibroin microparticles: their characterization and potential adsorption study

Badiadka Narayana

Papers

Complexometric determination of copper in isolation, alloys and complexes using DL-cysteine as a selective masking agent

N-(3-Chloro-4-fluoro­phen­yl)-2,2-diphenyl­acetamide

A facile spectrophotometric method for the determination of periodate using azure B

Selective complexometric determination of mercury with sulphite as indirect masking reagent

Facile fabrication of silk fibroin microparticles: their characterization and potential adsorption study

N-(3-Chloro-4-fluorophenyl)-2,2-diphenylacetamide