J. Appl. Cryst.の発刊に際して

The Pharmacological Basis of Therapeutics A Textbook of Pharmacology, Toxicology and Therapeutics for Physicians and Medical Students. By Prof. Louis Goodman and Prof. Alfred Gilman. Pp. xiii + 1383. (New York: The Macmillan Company, 1941.) 50s. net.

The Pharmacological Basis of Therapeutics

There is a special reason for reviewing this book at this time: it is the 50th edition of a compendium that is known and used frequently in most chemical and physical laboratories in many parts of the world. Surely, a publication that has been published for 56 years, withstanding the vagaries of science in this century, must have had something to offer. There is another reason: while the book is a standard fixture in most chemical and physical laboratories, including those in medical centers, it is not as frequently seen in the laboratories of physician's offices (those either in solo or group practice). I believe that the Handbook can be useful in those laboratories. One of the reasons, among others, is that the various basic items of information it offers may be helpful in new tests, either physical or chemical, which are continuously being published. The basic information may relate

Handbook of Chemistry and Physics

Chem. Pharm. Bull.(オピニオン)

We report a study of self-assembled beta-pleated sheets in B. mori silk fibroin films using thermal analysis and infrared spectroscopy. B. mori silk fibroin may stand as an exemplar of fibrous proteins containing crystalline beta-sheets. Materials were prepared from concentrated solutions (2−5 wt % fibroin in water) and then dried to achieve a less ordered state without beta-sheets. Crystallization of beta-pleated sheets was effected either by heating the films above the glass transition temperature (Tg) and holding isothermally or by exposure to methanol. The fractions of secondary structural components including random coils, alpha-helices, beta-pleated sheets, turns, and side chains were evaluated using Fourier self-deconvolution (FSD) of the infrared absorbance spectra. The silk fibroin films were studied thermally using temperature-modulated differential scanning calorimetry (TMDSC) to obtain the reversing heat capacity. The increment of the reversing heat capacity ΔCp0(Tg) at the glass transition fo...

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Determining Beta Sheet Crystallinity in Fibrous Proteins by Thermal Analysis and Infrared Spectroscopy

A simple and rapid spectrophotometric method for the determination of artemisinin (ART) and dihydroartemisinin (DHA) is described. The method is based on the reaction of hydrogen peroxide (H 2 O 2 ), generated by the cleavage of endoperoxide linkage of ART/DHA and its reaction with potassium iodide to liberate iodine. The liberated iodine bleaches the red coloured safranin O to colourless species and is measured at 521 nm. Beer's law is obeyed in the range of 16-112 μg mL -1 for both ART and DHA. The molar absorptivity, Sandell's sensitivity, detection limit and quantitation limit for ART were found to be 0.3401x10 4 Lmol -1 cm -1 , 1.43 x 10 -2 μg cm -2 , 0.0685 μg mL -1 and 0.2075 μg mL -1 respectively; while that for DHA were found to be 0.2891 x 10 4 L mol -1 cm -1 , 1.33 x 10 -2 μg cm -2 , 0.0491 μg mL -1 and 0.1488 μg mL -1 respectively. The optimum reaction conditions and other analytical parameters were evaluated. The statistical evaluation of the method was examined by determining intra-day and inter-day precision.

http://nopr.niscair.res.in/bitstream/123456789/867/1/IJCT%2015%281%29%20%282008%29%2059-62.pdf

Spectrophotometric determination of artemisinin and dihydroartemisinin

In the title compound, C14H16N2OS, the thia­zole ring is essentially planar (r.m.s. deviation = 0.005 A) and it forms a dihedral angle of 75.21 (8)° with the benzene ring. In the crystal, mol­ecules are linked into inversion dimers by pairs of N—H⋯N hydrogen bonds to generate R22(8) loops.

https://journals.iucr.org/e/issues/2012/08/00/hb6891/hb6891.pdf

N-(1,3-Thia-zol-2-yl)-2-(2,4,6-trimethyl-phen-yl)acetamide.

In the crystal structure of the title compound, C19H17Cl2N3O2, the mol­ecules form dimers of the R22(10) type through N—H⋯O hydrogen bonding. As a result of steric repulsion, the amide group is rotated with respect to both the dichloro­phenyl and 2,3-dihydro-1H-pyrazol-4-yl rings, making dihedral angles of 80.70 (13) and 64.82 (12)°, respectively. The dihedral angle between the dichloro­phenyl and 2,3-dihydro-1H-pyrazol-4-yl rings is 48.45 (5)° while that between the 2,3-dihydro-1H-pyrazol-4-yl and phenyl rings is 56.33 (6)°.

https://journals.iucr.org/e/issues/2013/01/00/bt6879/bt6879.pdf

2-(2,4-Dichloro-phen-yl)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide.

Synthesis of Some New 2‐(6‐Methoxy‐2‐naphthyl)‐5‐aryl‐1,3,4‐oxadiazoles as Possible Non‐steroidal Antiinflammatory and Analgesic Agents.

In the title compound, C25H21F2N3O3S, the morpholine ring adopts a chair conformation. The 1,3,4-oxadiazole-2(3H)-thione group makes dihedral angles of 78.69 (8), 53.56 (7) and 55.30 (9)° with the benzene rings. In the crystal, O—H⋯O, C—H⋯S and C—H⋯F hydrogen bonds linked the mol­ecules into layers lying parallel to the ab plane. Weak C—H⋯π inter­actions also occur.

https://journals.iucr.org/e/issues/2011/12/00/hb6502/hb6502.pdf

Badiadka Narayana

Papers

Spectrophotometric determination of artemisinin and dihydroartemisinin

N-(1,3-Thia-zol-2-yl)-2-(2,4,6-trimethyl-phen-yl)acetamide.

2-(2,4-Dichloro-phen-yl)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide.

Synthesis of Some New 2‐(6‐Methoxy‐2‐naphthyl)‐5‐aryl‐1,3,4‐oxadiazoles as Possible Non‐steroidal Antiinflammatory and Analgesic Agents.

5-(4,4''-Difluoro-5'-hy-droxy-1,1':3',1''-terphenyl-4'-yl)-3-(morpholin-4-ylmeth-yl)-1,3,4-oxadiazole-2(3H)-thione.