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Baltazar D. Aguda
Researcher at Ohio State University
Publications - 45
Citations - 3202
Baltazar D. Aguda is an academic researcher from Ohio State University. The author has contributed to research in topics: microRNA & Restriction point. The author has an hindex of 21, co-authored 45 publications receiving 3029 citations. Previous affiliations of Baltazar D. Aguda include Mathematical Biosciences Institute & University of the Philippines.
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Journal ArticleDOI
Detection of microRNA Expression in Human Peripheral Blood Microvesicles
Melissa Piper Hunter,Noura Ismail,Noura Ismail,Xiaoli Zhang,Baltazar D. Aguda,Eun Joo Lee,Lianbo Yu,Tao Xiao,Jeffrey Schafer,Mei-Ling Ting Lee,Thomas D. Schmittgen,S. Patrick Nana-Sinkam,David Jarjoura,Clay B. Marsh,Clay B. Marsh +14 more
TL;DR: This study is the first to identify and define miRNA expression in circulating plasma microvesicles of normal subjects, and provides a basis for future studies to determine the predictive role of peripheral blood miRNA signatures in human disease.
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MicroRNA regulation of a cancer network: Consequences of the feedback loops involving miR-17-92, E2F, and Myc
TL;DR: The oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc using the concept and model prediction of a “cancer zone.”
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Karyotype-specific microRNA signature in chronic lymphocytic leukemia.
Rosa Visone,Laura Z. Rassenti,Angelo Veronese,Angelo Veronese,Cristian Taccioli,Stefan Costinean,Baltazar D. Aguda,Stefano Volinia,Manuela Ferracin,Jeff Palatini,Veronica Balatti,Hansjuerg Alder,Massimo Negrini,Thomas J. Kipps,Carlo M. Croce +14 more
TL;DR: The use of the microRNA-based classifications may yield clinically useful biomarkers of tumor behavior in CLL, and IGHV unmutated, high expression of ZAP-70 protein, and low expression of themiR-223, miR-29c, mi R-29b, and miR -181 family were strongly associated with disease progression in Cll cases harboring 17p deletion.
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The kinetic origins of the restriction point in the mammalian cell cycle.
Baltazar D. Aguda,Y. Tang +1 more
TL;DR: A detailed model mechanism for the G1/S transition in the mammalian cell cycle is presented and analysed by computer simulation to investigate whether the kinetic origins of the restriction point (R‐point) can be identified.
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Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling
TL;DR: Examining the pro-inflammatory signaling networks developed a mathematical model to show the magnitude-dependent regulation of chondrocytic responses by compressive forces and lays initial groundwork for the identification of the thresholds in physical activities that can differentiate its favorable actions from its unfavorable consequences on joints.