Bancinyane Lynn Sibanda

TL;DR: Prediction of the tertiary structures of proteins may be carried out using a knowledge-based approach based on identification of analogies in secondary structures, motifs, domains or ligand interactions between a protein to be modelled and those of known three-dimensional structures.

TL;DR: A systematic classification of beta-hairpin structures which takes into account the polypeptide chain length and hydrogen bonding between the two antiparallel beta-strands is described and can be applied to comparative model building, modelling into electron density and in the prediction of conformation of Beta-hairpins to aid protein engineering.

TL;DR: A systematic technique for protein modelling that is applicable to the design of drugs, peptide vaccines and novel proteins is described, which simultaneously aligns the known tertiary structures, selects fragments from the structurally conserved regions on the basis of sequence homology, and builds on the loops selected from homologous proteins or a wider database.

TL;DR: It is shown that renin may have a three-dimensional structure similar to that of other aspartyl proteinases9–11, and that inhibitors of renin are of potential value in the treatment of certain forms of hypertension.

TL;DR: The data suggest that in many globular proteins the terminal regions fulfil a structural role, stabilizing the tertiary or quaternary structure to provide a framework for the active site.