Barak Hajaj

TL;DR: It is hypothesized that H2O2 activates a transcription factor which in turn up-regulates tpxD expression, which triggers a conformational change in CodY, resulting in enhanced binding to DNA and a schematic model illustrating the contribution of TpxD and CodY to pneumococcal global transcriptional response to H2 O2 is proposed.

TL;DR: This study shows that tpxD encodes a functional thiol peroxidase involved in the adjustment of H2O2 homeostasis in the cell, suggesting that TpxD constitutes a component of the organism's fundamental strategy to fine-tune cellular processes in response to H2 O2.

TL;DR: It is shown that double-stranded plasmid DNA with a 350 nm hydrodynamic diameter penetrates through membrane pores as narrow as 10 nm under pressure, and suggested that the supercoiled plasmids penetrate through these narrow pores by stretching into long hair-shaped flexible strands.

TL;DR: Electrophysiological evidence for AF promoting effects of RAP in rats is demonstrated and several molecular similarities between the effects ofRAP in large and small mammalian models are found.

TL;DR: FlaR’s roles in pneumococcal physiology and virulence, combined with its lack of significant homology to human proteins, point towards rFlaR as a vaccine candidate.