Barbara Bachmann

TL;DR: Two different microfluidic devices containing embedded sensor arrays are developed to monitor local oxygen levels to investigate oxygen consumption rates of 2D and 3D hydrogel-based cell cultures and the establishment of oxygen gradients within cell culture chambers, and how dynamic control of cyclic normoxic-hypoxic cell microenvironments can be readily accomplished using programmable flow profiles employing both gas-impermeable and gas- permeable microfluidity biochips.

TL;DR: This review presents recent advances in mechanobiological lab-on-a-chip systems and reports on lessons learned from these current Mechanobiological models.

TL;DR: Results show that fibrin hydrogels of 30 kPa Young’s modulus best guide chondrocyte redifferentiation resulting in a native-like morphology as well as induces the synthesis of physiologic ECM constituents such as glycosaminoglycans (sGAG) and collagen type II.

TL;DR: Results of the study indicate that the microtissue model emulates the basic characteristics of native cartilage and responds to biochemical injury, thus providing a new foundation for exploration of osteoarthritis pathophysiology in both human and veterinary patients.

TL;DR: Characterization of four functional biomedical-grade pressure sensitive adhesives for rapid prototyping applications including structuring precision, physical and optical properties as well as biocompatibilities shows that both simple and complex microdevices can be designed, fabricated and tested in less than 1 hour.