Patrick Schuller

TL;DR: To overcome the analytical limitations of organs-on-a-chip systems a variety of biosensors have been integrated to provide continuous data on organ-specific reactions and dynamic tissue responses including optical and electrochemical bios Sensors.

TL;DR: Characterization of four functional biomedical-grade pressure sensitive adhesives for rapid prototyping applications including structuring precision, physical and optical properties as well as biocompatibilities shows that both simple and complex microdevices can be designed, fabricated and tested in less than 1 hour.

TL;DR: Finite volume CFD simulations of different sized molecules vital for pre-vascular network formation into and out of the hydrogel constructs found that interstitial flow enhances growth factor supply to the cells in the bulk of the chamber but elutes cellular secretome, resulting in truncated, premature vascularization.

TL;DR: It is demonstrated that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible and reliable information on how systemic stress factors affectsynovial tissue architectures.

TL;DR: To advance nanoparticle risk assessment at the human placental barrier, this work has developed as proof-of-principle a highly integrated placenta-on-a-chip system containing embedded membrane-bound impedance microsensor arrays capable of non-invasively monitoring placental Barrier integrity.