Showing papers by "Barbara C. Furie published in 2011"

TL;DR: It is demonstrated using intravital microscopy that anti-β(2)-GP1 autoantibodies purified from the sera of patients with antiphospholipid syndrome complicated by thrombosis greatly amplify thrombus size after laser-induced vessel wall injury in live mice.

TL;DR: This study lays down a foundation for understanding the specificity of PAI-1 for uPA and tPA and provides a structural basis for further functional studies.

TL;DR: Mouse and human prothrombin active site specifically labeled with d-Phe-Pro-Arg-CH2Cl (FPR-ProT) inhibited tissue factor-initiated thrombin generation in platelet-rich and platelets-poor mouse and human plasmas and exhibited ∼10-fold more potent anticoagulant activity compared with ProTS195A as a result of conformational changes in the ProT catalytic domain.

TL;DR: Rutin was the most effective inhibitor and inhibited PDI reductase activity with an IC50 of 6.1 μM, indicating that rutin does not covalently bind PDI.

TL;DR: A role for ERp5 in thrombus formation was studied in the laser injury model of thrombosis in mouse cremaster arterioles using a rabbit polyclonal anti-ERp5 antibody, immunoaffinity purified against recombinant ER p5.