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Emeka Ifedigbo
Researcher at Brigham and Women's Hospital
Publications - 25
Citations - 3086
Emeka Ifedigbo is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Lung injury & Programmed cell death. The author has an hindex of 25, co-authored 25 publications receiving 2824 citations. Previous affiliations of Emeka Ifedigbo include Veterans Health Administration & Harvard University.
Papers
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Journal ArticleDOI
Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis.
Xiaomei Wang,Yingze Zhang,Hong Pyo Kim,Zhihong Zhou,Carol Feghali-Bostwick,Fang Liu,Emeka Ifedigbo,Xiaohui Xu,Tim D. Oury,Naftali Kaminski,Augustine M.K. Choi +10 more
TL;DR: Cav-1 was able to suppress TGF-β1–induced ECM production in cultured fibroblasts through the regulation of the c-Jun N-terminal kinase (JNK) pathway and suggests a novel therapeutic target for patients with pulmonary fibrosis.
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Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema
Zhi Hua Chen,Hilaire C. Lam,Hilaire C. Lam,Yang Jin,Hong Pyo Kim,Hong Pyo Kim,Jiaofei Cao,Jiaofei Cao,Seon Jin Lee,Emeka Ifedigbo,Harikrishnan Parameswaran,Stefan W. Ryter,Augustine M.K. Choi +12 more
TL;DR: A pivotal role is demonstrated for the autophagic proteinLC3B in CS-induced apoptosis and emphysema, suggestive of novel therapeutic targets for COPD treatment and a mechanism by which LC3B, through interactions with Cav-1 and Fas, can regulate apoptosis.
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Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury
Yorihiro Akamatsu,Manabu Haga,Shivraj Tyagi,Kenichiro Yamashita,Aurelio V. Graca-Souza,Robert Öllinger,Eva Czismadia,G. Aaron May,Emeka Ifedigbo,Leo E. Otterbein,Fritz H. Bach,Miguel P. Soares +11 more
TL;DR: Heme oxygenase‐1‐derived CO prevents IRI associated with cardiac transplantation based on its antiapoptotic action and the observation that exposure of the donor and the graft to CO is sufficient to afford this protective effect should have important clinical implications in terms of preventing I RI associated with heart transplantation in humans.
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Nitrite Potently Inhibits Hypoxic and Inflammatory Pulmonary Arterial Hypertension and Smooth Muscle Proliferation via Xanthine Oxidoreductase–Dependent Nitric Oxide Generation
Brian S. Zuckerbraun,Sruti Shiva,Emeka Ifedigbo,Michael A. Mathier,Kevin P. Mollen,Jayashree Rao,Philip M. Bauer,Justin J Choi,Erin Curtis,Augustine M.K. Choi,Mark T. Gladwin,Mark T. Gladwin +11 more
TL;DR: A potent effect of inhaled nitrite that limits pathological pulmonary arterial hypertrophy and cellular proliferation in the setting of experimental pulmonary arterials hypertension is revealed.
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Autophagic Protein LC3B Confers Resistance against Hypoxia-induced Pulmonary Hypertension
Seon Jin Lee,Akaya Smith,Lanping Guo,Tero-Pekka Alastalo,Molong Li,Hirofumi Sawada,Xiaoli Liu,Zhi Hua Chen,Emeka Ifedigbo,Yang Jin,Carol Feghali-Bostwick,Stefan W. Ryter,Hong Pyo Kim,Hong Pyo Kim,Marlene Rabinovitch,Augustine M.K. Choi +15 more
TL;DR: The results suggest that autophagic protein LC3B exerts a protective function during the pathogenesis of PH, through the regulation of hypoxic cell proliferation.