B
Bärbel Hahn-Hägerdal
Researcher at Lund University
Publications - 272
Citations - 27781
Bärbel Hahn-Hägerdal is an academic researcher from Lund University. The author has contributed to research in topics: Xylose & Fermentation. The author has an hindex of 83, co-authored 271 publications receiving 26753 citations. Previous affiliations of Bärbel Hahn-Hägerdal include Stellenbosch University & Technical University of Denmark.
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Journal ArticleDOI
Identification of common traits in improved xylose‐growing Saccharomyces cerevisiae for inverse metabolic engineering
Oskar Bengtsson,Marie Jeppsson,Marco Sonderegger,Nádia Skorupa Parachin,Uwe Sauer,Bärbel Hahn-Hägerdal,Marie F. Gorwa-Grauslund +6 more
TL;DR: Four recombinant Saccharomyces cerevisiae strains with enhanced xylose growth were compared with two control strains through genome‐wide transcription analysis in order to identify novel targets for inverse metabolic engineering.
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Dynamic metabolomics differentiates between carbon and energy starvation in recombinant Saccharomyces cerevisiae fermenting xylose
TL;DR: The low uptake of xylose by the XI-strain led to several distinguished responses: depletion of key metabolites in glycolysis and NADPH, a reduced GTP/GDP ratio and accumulation of PEP and aromatic amino acids are strong indicators of carbon starvation.
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Xylose isomerase activity influences xylose fermentation with recombinant Saccharomyces cerevisiae strains expressing mutated xylA from Thermus thermophilus.
TL;DR: Three xylose isomerase enzymes (XI) were produced at two different levels in Saccharomyces cerevisiae; xylA genes were chromosomally integrated and expressed from multicopy plasmids, respectively.
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Xylulose fermentation by Saccharomyces cerevisiae and xylose-fermenting yeast strains
TL;DR: Xylulose fermentation by four strains of Saccharomyces cerevisiae and two strains of xylose-fermenting yeasts, Pichia stipitis CBS 6054 and Candida shehatae NJ 23, was compared using a mineral medium at a cell concentration of 10 g (dry weight)/l.
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Analysis of the hypoxia-induced ADH2 promoter of the respiratory yeast Pichia stipitis reveals a new mechanism for sensing of oxygen limitation in yeast.
Volkmar Passoth,Volkmar Passoth,Marita Cohn,Bernd Schäfer,Bärbel Hahn-Hägerdal,Ulrich Klinner +5 more
TL;DR: The very first promoter analysis in P. stipitis revealed a hitherto unknown mechanism of oxygen sensing in yeast, which has similarities to the mammalian HIF‐1 system, which is inducible by Co2+ but not by cyanide.