Barbro Werelius

TL;DR: Two SNPs consistently associated with breast cancer are identified: rs3803662 is near the 5′ end of TNRC9 , a high mobility group chromatin–associated protein whose expression is implicated in breast cancer metastasis to bone.

TL;DR: Tight linkage is presented between a polymorphic marker on the short arm of chromosome 3 and the disease locus, and it is found that families with hereditary–non polyposis colon cancer also manifest signs of a general DNA replication disorder.

TL;DR: The present results indicate that the SCE-frequency in healthy human subjects is influenced by individual smoking habits as well and strongly suggest occupational exposure as a causative factor.

TL;DR: It is demonstrated in one family that a hMLH3 mutation segregated with disease together with a missense mutation in hMSH2, which makes it hypothesize that these mutations work together in an additive manner and result in an elevated risk of colorectal tumors in the family.

TL;DR: Results do not support CDH1 as a prominent low‐penetrance cancer susceptibility gene, but indicate thatCDH1 mutations contribute to the progression of both lobular and ductal tumors.