T
Thorunn Rafnar
Researcher at deCODE genetics
Publications - 158
Citations - 26350
Thorunn Rafnar is an academic researcher from deCODE genetics. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 65, co-authored 146 publications receiving 23774 citations. Previous affiliations of Thorunn Rafnar include Amgen.
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Journal ArticleDOI
Erratum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer (Nature Genetics (2009) 41 (991-995))
Xifeng Wu,Yuanqing Ye,Lambertus A. Kiemeney,Patrick Sulem,Thorunn Rafnar,Giuseppe Matullo,Daniela Seminara,Teruhiko Yoshida,Norihisa Saeki,Angeline S. Andrew,Colin P.N. Dinney,Bogdan Czerniak,Zuo-Feng Zhang,Anne E. Kiltie,D. Timothy Bishop,Paolo Vineis,Stefano Porru,Frank Buntinx,Eliane Kellen,Maurice P. Zeegers,Rajesh Kumar,Peter Rudnai,Eugene Gurzau,Kvetoslava Koppova,Jose I. Mayordomo,Manuel Sanchez,Berta Saez,Annika Lindblom,Petra J. de Verdier,Gunnar Steineck,Gordon B. Mills,Alan R. Schned,Shen Chih Chang,Jie Lin,David W. Chang,Katherine S. Hale,Tadeusz Majewski,H. Barton Grossman,Steinunn Thorlacius,Unnur Thorsteinsdottir,Katja K.H. Aben,J. Alfred Witjes,Kari Stefansson,Christopher I. Amos,Margaret R. Karagas,Jian Gu +45 more
TL;DR: In the version of this article initially published online, Simonetta Guarrera and Silvia Polidoro were inadvertently omitted from the author list, and an affiliation was omitted for Paolo Vineis as mentioned in this paper.
Journal ArticleDOI
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
Thorgeir E. Thorgeirsson,Frank Geller,Patrick Sulem,Thorunn Rafnar,Anna Wiste,Anna Wiste,Kristinn P. Magnusson,Andrei Manolescu,Gudmar Thorleifsson,Hreinn Stefansson,Andres Ingason,Simon N. Stacey,Jon Thor Bergthorsson,Steinunn Thorlacius,Julius Gudmundsson,Thorlakur Jonsson,Margret Jakobsdottir,Jona Saemundsdottir,Olof Birna Olafsdottir,Larus J. Gudmundsson,Gyda Bjornsdottir,Kristleifur Kristjansson,Halla Skuladottir,Helgi J Isaksson,Tomas Gudbjartsson,Gregory T. Jones,Thomas Mueller,Anders Gottsäter,Andrea Flex,Katja K.H. Aben,Femmie de Vegt,Peter F.A. Mulders,Dolores Isla,Maria Vidal,Laura Asín,Berta Saez,L. Murillo,Thorsteinn Blondal,Halldor Kolbeinsson,Jón G. Stefánsson,Ingunn Hansdottir,Valgerdur Runarsdottir,Roberto Pola,Bengt Lindblad,Andre M. van Rij,Benjamin Dieplinger,Meinhard Haltmayer,Jose I. Mayordomo,Lambertus A. Kiemeney,Stefan E Matthiasson,Hogni Oskarsson,Thorarinn Tyrfingsson,Daniel F. Gudbjartsson,Jeffrey R. Gulcher,Steinn Jonsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson,Kari Stefansson +59 more
TL;DR: A common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking-related diseases in populations of European descent is identified.
Journal ArticleDOI
Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma
Bhairavi Swaminathan,Guðmar Thorleifsson,Magnus Jöud,Mina Ali,Ellinor Johnsson,Ram Ajore,Patrick Sulem,Britt-Marie Halvarsson,Guðmundur I Eyjólfsson,Vilhelmina Haraldsdottir,Christina M. Hultman,Erik Ingelsson,Sigurður Yngvi Kristinsson,Anna K. Kähler,Stig Lenhoff,Gisli Masson,Ulf-Henrik Mellqvist,Robert Månsson,Sven Nelander,Isleifur Olafsson,Ólöf Sigurðardóttir,Hlif Steingrimsdottir,Annette Juul Vangsted,Ulla Vogel,Anders Waage,Hareth Nahi,Daniel F. Gudbjartsson,Thorunn Rafnar,Ingemar Turesson,Urban Gullberg,Kari Stefansson,Markus Hansson,Unnur Thorsteinsdottir,Björn Nilsson,Björn Nilsson +34 more
TL;DR: A genome-wide association study in the Nordic region identifying a novel MM risk locus at ELL2 that encodes a stoichiometrically limiting component of the super-elongation complex that drives secretory-specific immunoglobulin mRNA production and transcriptional regulation in plasma cells is reported.
Journal ArticleDOI
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Gudmar Thorleifsson,G. Bragi Walters,Daniel F. Gudbjartsson,Valgerdur Steinthorsdottir,Patrick Sulem,Anna Helgadottir,Unnur Styrkarsdottir,Solveig Gretarsdottir,Steinunn Thorlacius,Ingileif Jonsdottir,Ingileif Jonsdottir,Thorbjorg Jonsdottir,Elinborg J Olafsdottir,Gudridur H Olafsdottir,Thorvaldur Jonsson,Frosti Jonsson,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Hansen,Gitte Andersen,Torben Jørgensen,Torben Jørgensen,Torsten Lauritzen,Katja K.H. Aben,André L. M. Verbeek,Nel Roeleveld,Ellen Kampman,Lisa R. Yanek,Lewis C. Becker,Laufey Tryggvadottir,Thorunn Rafnar,Diane M. Becker,Jeffrey R. Gulcher,Lambertus A. Kiemeney,Oluf Pedersen,Oluf Pedersen,Augustine Kong,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +40 more
TL;DR: In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 × 10−7 and included previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.
Journal ArticleDOI
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
Julius Gudmundsson,Patrick Sulem,Andrei Manolescu,Laufey T. Amundadottir,Daniel F. Gudbjartsson,Agnar Helgason,Thorunn Rafnar,Jon Thor Bergthorsson,Bjarni A. Agnarsson,Adam Baker,Asgeir Sigurdsson,Kristrun R. Benediktsdottir,Margret Jakobsdottir,Jianfeng Xu,Thorarinn Blondal,Jelena Kostic,Jielin Sun,Shyamali Ghosh,Simon N. Stacey,Magali Mouy,Jona Saemundsdottir,Valgerdur M Backman,Kristleifur Kristjansson,Alejandro Tres,Alan W. Partin,Marjo T Albers-Akkers,Javier Godino-Ivan Marcos,Patrick C. Walsh,Dorine W. Swinkels,Sebastian Navarrete,Sarah D. Isaacs,Katja K.H. Aben,Theresa Graif,John Cashy,M. Ruiz-Echarri,Kathleen E. Wiley,Brian K. Suarez,J. Alfred Witjes,Mike Frigge,Carole Ober,Eirikur Jonsson,Gudmundur V. Einarsson,Jose I. Mayordomo,Lambertus A. Kiemeney,William B. Isaacs,William J. Catalona,Rosa B. Barkardottir,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +50 more
TL;DR: A second genetic variant in the 8q24 region that, in conjunction with another variant recently discovered, accounts for about 11%–13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans is reported.