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Valgerdur M Backman
Researcher at deCODE genetics
Publications - 5
Citations - 4643
Valgerdur M Backman is an academic researcher from deCODE genetics. The author has contributed to research in topics: Linkage disequilibrium & Genome-wide association study. The author has an hindex of 5, co-authored 5 publications receiving 4505 citations.
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Journal ArticleDOI
A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction
Anna Helgadottir,Gudmar Thorleifsson,Andrei Manolescu,Solveig Gretarsdottir,Thorarinn Blondal,Aslaug Jonasdottir,Abalbjorg Jonasdottir,Asgeir Sigurdsson,Adam Baker,Arnar Palsson,Gisli Masson,Daniel F. Gudbjartsson,Kristinn P. Magnusson,Karl Andersen,Allan I. Levey,Valgerdur M Backman,Sigurborg Matthiasdottir,Thorbjorg Jonsdottir,Stefan T Palsson,Helga Einarsdottir,Steinunn Gunnarsdottir,Arnaldur Gylfason,Viola Vaccarino,W. Craig Hooper,Muredach P. Reilly,Christopher B. Granger,Harland Austin,Daniel J. Rader,Svati H. Shah,Arshed A. Quyyumi,Jeffrey R. Gulcher,Gudmundur Thorgeirsson,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +34 more
TL;DR: An association between myocardial infarction and a common sequence variant on chromosome 9p21 was associated with the disease with high significance and approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardious disease is 1.64 times as great as that of noncarriers.
Journal ArticleDOI
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
Julius Gudmundsson,Patrick Sulem,Andrei Manolescu,Laufey T. Amundadottir,Daniel F. Gudbjartsson,Agnar Helgason,Thorunn Rafnar,Jon Thor Bergthorsson,Bjarni A. Agnarsson,Adam Baker,Asgeir Sigurdsson,Kristrun R. Benediktsdottir,Margret Jakobsdottir,Jianfeng Xu,Thorarinn Blondal,Jelena Kostic,Jielin Sun,Shyamali Ghosh,Simon N. Stacey,Magali Mouy,Jona Saemundsdottir,Valgerdur M Backman,Kristleifur Kristjansson,Alejandro Tres,Alan W. Partin,Marjo T Albers-Akkers,Javier Godino-Ivan Marcos,Patrick C. Walsh,Dorine W. Swinkels,Sebastian Navarrete,Sarah D. Isaacs,Katja K.H. Aben,Theresa Graif,John Cashy,M. Ruiz-Echarri,Kathleen E. Wiley,Brian K. Suarez,J. Alfred Witjes,Mike Frigge,Carole Ober,Eirikur Jonsson,Gudmundur V. Einarsson,Jose I. Mayordomo,Lambertus A. Kiemeney,William B. Isaacs,William J. Catalona,Rosa B. Barkardottir,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +50 more
TL;DR: A second genetic variant in the 8q24 region that, in conjunction with another variant recently discovered, accounts for about 11%–13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans is reported.
Journal ArticleDOI
Variants conferring risk of atrial fibrillation on chromosome 4q25
Daniel F. Gudbjartsson,David O. Arnar,Anna Helgadottir,Solveig Gretarsdottir,Hilma Holm,Asgeir Sigurdsson,Adalbjorg Jonasdottir,Adam Baker,Gudmar Thorleifsson,Kristleifur Kristjansson,Arnar Palsson,Thorarinn Blondal,Patrick Sulem,Valgerdur M Backman,Gudmundur A. Hardarson,Ebba Palsdottir,Agnar Helgason,Runa Sigurjonsdottir,Jon Th. Sverrisson,Konstantinos Kostulas,Maggie C.Y. Ng,Larry Baum,Wing-Yee So,Ka Sing Wong,Juliana C.N. Chan,Karen L. Furie,Steven M. Greenberg,Michelle Sale,Peter J. Kelly,Calum A. MacRae,Eric E. Smith,Jonathan Rosand,Jan Hillert,Ronald C.W. Ma,Patrick T. Ellinor,Gudmundur Thorgeirsson,Jeffrey R. Gulcher,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson +39 more
TL;DR: A genome-wide association scan is performed, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and a strong association is found between two sequence variants on chromosome 4q25 and AF.
Journal ArticleDOI
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.
Simon N. Stacey,Andrei Manolescu,Patrick Sulem,Thorunn Rafnar,Julius Gudmundsson,Sigurjon A. Gudjonsson,Gisli Masson,Margret Jakobsdottir,Steinunn Thorlacius,Agnar Helgason,Katja K.H. Aben,Luc J Strobbe,Marjo T Albers-Akkers,Dorine W. Swinkels,Brian E. Henderson,Laurence N. Kolonel,Loic Le Marchand,Esther Millastre,Raquel Andrés,Javier Godino,Maria D. Garcia-Prats,E. Polo,Alejandro Tres,Magali Mouy,Jona Saemundsdottir,Valgerdur M Backman,Larus J. Gudmundsson,Kristleifur Kristjansson,Jon Thor Bergthorsson,Jelena Kostic,Michael L. Frigge,Frank Geller,Daniel F. Gudbjartsson,Helgi Sigurdsson,Thora Jonsdottir,Jon Hrafnkelsson,Jakob Johannsson,Thorarinn Sveinsson,Gardar Myrdal,Hlynur Niels Grimsson,Thorvaldur Jonsson,Susanna von Holst,Barbro Werelius,Sara Margolin,Annika Lindblom,Jose I. Mayordomo,Christopher A. Haiman,Lambertus A. Kiemeney,Oskar T. Johannsson,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +52 more
TL;DR: Two SNPs consistently associated with breast cancer are identified: rs3803662 is near the 5′ end of TNRC9 , a high mobility group chromatin–associated protein whose expression is implicated in breast cancer metastasis to bone.
Journal ArticleDOI
A common variant on chromosome 9p21 affects the risk of myocardial infarction
Anna Helgadottir,Gudmar Thorleifsson,Andrei Manolescu,Solveig Gretarsdottir,Thorarinn Blondal,Aslaug Jonasdottir,Abalbjorg Jonasdottir,Asgeir Sigurdsson,Adam Baker,Arnar Palsson,Gisli Masson,Daniel F. Gudbjartsson,Kristinn P. Magnusson,Karl Andersen,Allan I. Levey,Valgerdur M Backman,Sigurborg Matthiasdottir,Thorbjorg Jonsdottir,Stefan T Palsson,Helga Einarsdottir,Steinunn Gunnarsdottir,Arnaldur Gylfason,Viola Vaccarino,W. Craig Hooper,Muredach P. Reilly,Christopher B. Granger,Harland Austin,Daniel J. Rader,Svati H. Shah,Arshed A. Quyyumi,Jeffrey R. Gulcher,Gudmundur Thorgeirsson,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +34 more
TL;DR: An association between myocardial infarction and a common sequence variant on chromosome 9p21 was associated with the disease with high significance and approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardious disease is 1.64 times as great as that of noncarriers.