J
Jeffrey W. Touchman
Researcher at National Institutes of Health
Publications - 24
Citations - 6751
Jeffrey W. Touchman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Sequence analysis & Genome. The author has an hindex of 20, co-authored 24 publications receiving 6508 citations. Previous affiliations of Jeffrey W. Touchman include Translational Genomics Research Institute.
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Journal ArticleDOI
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Robert L. Strausberg,Elise A. Feingold,Lynette H. Grouse,Jeffery G. Derge,Richard D. Klausner,Francis S. Collins,Lukas Wagner,Carolyn M. Shenmen,Gregory D. Schuler,Stephen F. Altschul,Barry R. Zeeberg,Kenneth H. Buetow,Carl F. Schaefer,Narayan K. Bhat,Ralph F. Hopkins,Heather Jordan,Troy Moore,Steve I Max,Jun Wang,Florence Hsieh,Luda Diatchenko,Kate Marusina,Andrew A Farmer,Gerald M. Rubin,Ling Hong,Mark Stapleton,M. Bento Soares,Maria de Fatima Bonaldo,Thomas L. Casavant,Todd E. Scheetz,Michael J. Brownstein,Ted B. Usdin,Shiraki Toshiyuki,Piero Carninci,Christa Prange,Sam S Raha,Naomi A Loquellano,Garrick J Peters,Rick D Abramson,Sara J Mullahy,Stephanie Bosak,Paul J. McEwan,Kevin McKernan,Joel A. Malek,Preethi H. Gunaratne,Stephen Richards,Kim C. Worley,Sarah Hale,Angela M. Garcia,Stephen W. Hulyk,Debbie K Villalon,Donna M. Muzny,Erica Sodergren,Xiuhua Lu,Richard A. Gibbs,Jessica Fahey,Erin Helton,Mark Ketteman,Anuradha Madan,Stephanie Rodrigues,Amy Sanchez,Michelle Whiting,Anup Madan,Alice C. Young,Yuriy O. Shevchenko,Gerard G. Bouffard,Robert W. Blakesley,Jeffrey W. Touchman,Eric D. Green,Mark Dickson,Alex Rodriguez,Jane Grimwood,Jeremy Schmutz,Richard M. Myers,Yaron S.N. Butterfield,Martin Krzywinski,Ursula Skalska,Duane E. Smailus,Angelique Schnerch,Jacqueline E. Schein,Steven J.M. Jones,Marco A. Marra +81 more
TL;DR: The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify and sequence a cDNA clone containing a complete ORF for each human and mouse gene.
Journal ArticleDOI
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
John D. Carpten,Andrew L. Faber,Candice Horn,Gregory P. Donoho,Stephen L. Briggs,Christiane M. Robbins,Galen Hostetter,Sophie Boguslawski,Tracy Moses,Stephanie Savage,Mark Uhlik,Aimin Lin,Jian Du,Yue-Wei Qian,Douglas J. Zeckner,Greg Tucker-Kellogg,Jeffrey W. Touchman,Ketan J. Patel,Spyro Mousses,Michael L. Bittner,Richard W. Schevitz,Mei-Huei T. Lai,Kerry L. Blanchard,James E. Thomas +23 more
TL;DR: The identification of a somatic mutation in human breast, colorectal and ovarian cancers that results in a glutamic acid to lysine substitution at amino acid 17 (E17K) in the lipid-binding pocket of AKT1 is reported.
Journal ArticleDOI
Comparative analyses of multi-species sequences from targeted genomic regions
James W. Thomas,James W. Thomas,Jeffrey W. Touchman,Robert W. Blakesley,Gerry Bouffard,Stephen M. Beckstrom-Sternberg,Elliott H. Margulies,Mathieu Blanchette,Adam Siepel,Pamela J. Thomas,Jenny McDowell,Baishali Maskeri,Nancy F. Hansen,M. S. Schwartz,R. J. Weber,W. J. Kent,Donna Karolchik,T. C. Bruen,R. Bevan,David J. Cutler,Scott Schwartz,Laura Elnitski,Jacquelyn R. Idol,Arjun B. Prasad,Shih-Queen Lee-Lin,Valerie Maduro,Tyrone J. Summers,Matthew E. Portnoy,Nicole Dietrich,N. Akhter,K. Ayele,Betty Benjamin,K. Cariaga,Charles P. Brinkley,Shelise Brooks,S. Granite,Xin-Yuan Guan,Jyoti Gupta,P. Haghighi,S. L. Ho,M. C. Huang,Eric Karlins,P. L. Laric,Richelle Legaspi,M. J. Lim,Quino Maduro,Cathy Masiello,Stephen D. Mastrian,J. C. McCloskey,R. Pearson,Sirintorn Stantripop,Emmanuelle Tiongson,J. T. Tran,C. Tsurgeon,Jennifer Vogt,M. A. Walker,Keith Wetherby,L. S. Wiggins,Alice C. Young,L. H. Zhang,Kazutoyo Osoegawa,Baoli Zhu,B. Zhao,C. L. Shu,P. J. De Jong,Charles E. Lawrence,Arian F.A. Smit,Aravinda Chakravarti,David Haussler,Philip Green,Webb Miller,Eric D. Green +71 more
TL;DR: The generation and analysis of over 12 megabases of sequence from 12 species, all derived from the genomic region orthologous to a segment of about 1.8 Mb on human chromosome 7 containing ten genes, show conservation reflecting both functional constraints and the neutral mutational events that shaped this genomic region.
Journal ArticleDOI
Association of Unconventional Myosin MYO15 Mutations with Human Nonsyndromic Deafness DFNB3
Aihui Wang,Yong Liang,Robert A. Fridell,Frank J. Probst,Edward R. Wilcox,Jeffrey W. Touchman,Cynthia C. Morton,Robert J. Morell,Konrad Noben-Trauth,Sally A. Camper,Thomas B. Friedman +10 more
TL;DR: A human unconventional myosin gene, MYO15, was identified by combining functional and positional cloning approaches in searching for shaker-2 and DFNB3, revealing two missense mutations and one nonsense mutation that cosegregated with congenital recessive deafness.
Journal ArticleDOI
Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene
Frank J. Probst,Robert A. Fridell,Yehoash Raphael,Thomas L. Saunders,Aihui Wang,Yong Liang,Robert J. Morell,Jeffrey W. Touchman,Robert H. Lyons,Konrad Noben-Trauth,Thomas B. Friedman,Sally A. Camper +11 more
TL;DR: Shaker-2 mice were found to have an amino acid substitution at a highly conserved position within the motor domain of this myosin this article, which suggests that Myo15 is necessary for actin organization in the hair cells of the cochlea.