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Bart J. L. Eggen
Researcher at University Medical Center Groningen
Publications - 140
Citations - 7317
Bart J. L. Eggen is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Microglia & Medicine. The author has an hindex of 43, co-authored 119 publications receiving 5542 citations. Previous affiliations of Bart J. L. Eggen include Rockefeller University & University of Groningen.
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Journal ArticleDOI
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
Thais F. Galatro,Thais F. Galatro,Inge R. Holtman,Antonio M. Lerario,Ilia D. Vainchtein,Nieske Brouwer,Paula R. Sola,Mariana Matera Veras,Tulio Felipe Pereira,Renata Elaine Paraizo Leite,Thomas Möller,Paul D. Wes,Mari Cleide Sogayar,Jon D. Laman,Wilfred F. A. den Dunnen,Carlos Augusto Pasqualucci,Sueli Mieko Oba-Shinjo,Erik Boddeke,Suely Kazue Nagahashi Marie,Bart J. L. Eggen +19 more
TL;DR: Age-associated changes in human microglia were enriched for genes involved in cell adhesion, axonal guidance, cell surface receptor expression and actin (dis)assembly, indicating that human and mouse microglian age differently.
Journal ArticleDOI
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
Inge R. Holtman,Divya Raj,Jeremy A. Miller,Wandert Schaafsma,Zhuoran Yin,Nieske Brouwer,Paul D. Wes,Thomas Möller,Marie Orre,Willem Kamphuis,Elly M. Hol,Elly M. Hol,Elly M. Hol,Erik Boddeke,Bart J. L. Eggen +14 more
TL;DR: Microglia priming induces a highly conserved transcriptional signature with aging- and disease-specific aspects that prominently differed from the acute inflammatory gene network induced by lipopolysaccharide (LPS).
Journal ArticleDOI
Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.
Frank Szulzewsky,Andreas Pelz,Xi Feng,Michael Synowitz,Darko Markovic,Thomas Langmann,Inge R. Holtman,Xi Wang,Bart J. L. Eggen,Hendrikus Boddeke,Dolores Hambardzumyan,Susanne A. Wolf,Helmut Kettenmann +12 more
TL;DR: It is demonstrated that the expression of Gpnmb and Spp1 is highly upregulated in both murine and human glioma-associated microglia/macrophage phenotype including a mixture of M1 and M2a,b,c-specific genes.
Journal ArticleDOI
A novel microglial subset plays a key role in myelinogenesis in developing brain
Agnieszka Wlodarczyk,Inge R. Holtman,Martin Krueger,Nir Yogev,Julia Bruttger,Reza Khorooshi,Anouk Benmamar-Badel,Anouk Benmamar-Badel,Jelkje J. de Boer-Bergsma,Nellie Anne Martin,Khalad Karram,Isabella Kramer,Erik Boddeke,Ari Waisman,Bart J. L. Eggen,Trevor Owens +15 more
TL;DR: It is shown that in contrast to healthy adult and inflammation‐activated cells, neonatal microglia show a unique myelinogenic and neurogenic phenotype that deliver signals necessary for myelination and neurogenesis.
Journal ArticleDOI
Identification of a microglia phenotype supportive of remyelination
Marta Olah,Sandra Amor,Sandra Amor,Nieske Brouwer,Jonathan Vinet,Bart J. L. Eggen,Knut Biber,Knut Biber,Hendrikus Boddeke +8 more
TL;DR: The notion that the primary function of microglia is the maintenance of tissue homeostasis and the support of regeneration already at the earliest stages in the development of demyelinating lesions is reinforced.