X
Xi Wang
Researcher at German Cancer Research Center
Publications - 57
Citations - 3209
Xi Wang is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 22, co-authored 38 publications receiving 2334 citations. Previous affiliations of Xi Wang include Heidelberg University & University of Newcastle.
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Journal ArticleDOI
Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity
Xintian You,Irena Vlatkovic,Ana Babic,Tristan J. Will,Irina Epstein,Georgi Tushev,Güney Akbalik,Mantian Wang,Caspar Glock,Claudia Quedenau,Xi Wang,Jingyi Hou,Hongyu Liu,Wei Sun,Sivakumar Sambandan,Tao Chen,Erin M. Schuman,Wei Chen +17 more
TL;DR: The data indicate that brain circRNAs are positioned to respond to and regulate synaptic function and exhibited substantial up- or downregulation following a homeostatic downscaling of neuronal activity.
Journal ArticleDOI
Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.
Frank Szulzewsky,Andreas Pelz,Xi Feng,Michael Synowitz,Darko Markovic,Thomas Langmann,Inge R. Holtman,Xi Wang,Bart J. L. Eggen,Hendrikus Boddeke,Dolores Hambardzumyan,Susanne A. Wolf,Helmut Kettenmann +12 more
TL;DR: It is demonstrated that the expression of Gpnmb and Spp1 is highly upregulated in both murine and human glioma-associated microglia/macrophage phenotype including a mixture of M1 and M2a,b,c-specific genes.
Journal ArticleDOI
Polylox barcoding reveals haematopoietic stem cell fates realized in vivo
Weike Pei,Thorsten B. Feyerabend,Jens Rössler,Xi Wang,Daniel Postrach,Katrin Busch,Immanuel Rode,Kay Klapproth,Nikolaus Dietlein,Claudia Quedenau,Wei Chen,Sascha Sauer,Stephan Wolf,Thomas Höfer,Thomas Höfer,Hans Reimer Rodewald +15 more
TL;DR: The development of an artificial DNA recombination locus (termed Polylox) is reported that enables broadly applicable endogenous barcoding based on the Cre–loxP recombination system and reaches a practical diversity of several hundred thousand barcodes, allowing tagging of single cells.
Journal ArticleDOI
Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation
Erik McShane,Celine Sin,Henrick Zauber,Jonathan N. Wells,Neysan Donnelly,Xi Wang,Jingyi Hou,Wei Chen,Zuzana Storchova,Joseph A. Marsh,Angelo Valleriani,Matthias Selbach,Matthias Selbach +12 more
TL;DR: Together, the data show that non-exponentially degradation is common, conserved, and has important consequences for complex formation and regulation of protein abundance.
Journal ArticleDOI
Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity.
Jing Ni,Jing Ni,Xi Wang,Ana Stojanovic,Ana Stojanovic,Qin Zhang,Marian Wincher,Lea Bühler,Annette Arnold,Margareta P. Correia,Margareta P. Correia,Manuel Winkler,Philipp-Sebastian Koch,Veronika Sexl,Thomas Höfer,Adelheid Cerwenka,Adelheid Cerwenka +16 more
TL;DR: The transcriptional landscape of mouse tumor-infiltrating natural killer cells is defined by using single-cell RNA sequencing and inhibition of HIF-1α unleashes NK cell anti-tumor activity and could be exploited for cancer therapy.