Bas Teusink

TL;DR: This work proves mathematically that the resulting optimal metabolic flux distribution is described by a limited number of subnetworks, known as Elementary Flux Modes (EFMs), and finds that the maximal number of flux-carrying EFMs is determined only by the number of imposed constraints on enzyme expression, not by the size, kinetics or topology of the network.

TL;DR: Under conditions of LDLR deficiency in combination with high fat feeding or prolonged fasting, the effect of the VLDLR on VLDL triglyceride metabolism was revealed and it is suggested that the V LDLR affects peripheral uptake of V LDL triglycerides.

TL;DR: It is argued that the inference of the community structure from experimental data is a major current challenge and requires mathematical models that can integrate heterogeneous experimental data with existing knowledge, and it is proposed that two types of models are needed.

TL;DR: This study characterize maximal‐specific‐rate states of metabolic networks of arbitrary size and complexity, including genome‐scale kinetic models and reports that optimal states are elementary flux modes, which are minimal metabolic networks operating at a thermodynamically‐feasible steady state with one independent flux.

TL;DR: Conditions of slow growth and limited substrate availability seem to trigger a plant environment‐like response, even in the absence of plant‐derived material, suggesting that this might constitute an intrinsic behavior in L. plantarum.