B
Beata Majchrzak
Researcher at University of Toronto
Publications - 27
Citations - 2270
Beata Majchrzak is an academic researcher from University of Toronto. The author has contributed to research in topics: MAP2K7 & Signal transduction. The author has an hindex of 24, co-authored 27 publications receiving 2200 citations. Previous affiliations of Beata Majchrzak include University Health Network & University of Illinois at Chicago.
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Journal ArticleDOI
Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons
Shahab Uddin,Beata Majchrzak,Joanna Woodson,Pony Arunkumar,Yazan Alsayed,Richard Pine,Peter R. Young,Eleanor N. Fish,Leonidas C. Platanias +8 more
TL;DR: Evidence is provided that the p38 Map kinase is rapidly phosphorylated and activated during treatment of cells with Type I interferons (IFNα and IFNβ) and plays a critical role ininterferon signaling and interferon-dependent transcriptional regulation.
Journal ArticleDOI
Protein kinase C-δ (PKC-δ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727
Shahab Uddin,Antonella Sassano,Dilip K. Deb,Amit Verma,Beata Majchrzak,Arshad Rahman,Asrar B. Malik,Eleanor N. Fish,Leonidas C. Platanias +8 more
TL;DR: Findings indicate that PKC-δ functions as a serine kinase for Stat1 and an upstream regulator of the p38 MAP kinase and plays an important role in the induction of Type I IFN-biological responses.
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The Rac1/p38 Mitogen-activated Protein Kinase Pathway Is Required for Interferon α-dependent Transcriptional Activation but Not Serine Phosphorylation of Stat Proteins
Shahab Uddin,Fatima Lekmine,Niti Sharma,Beata Majchrzak,Ingrid A. Mayer,Peter R. Young,Gary M. Bokoch,Eleanor N. Fish,Leonidas C. Platanias +8 more
TL;DR: Evidence is provided that the small GTPase Rac1 is activated in a type I IFN-dependent manner and that its function is required for downstream engagement of the p38 MAP kinase pathway, to regulate transcriptional regulation of IFNalpha-sensitive genes and generation of growth inhibitory responses.
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The p38 MAPK Pathway Mediates the Growth Inhibitory Effects of Interferon-α in BCR-ABL-expressing Cells
Ingrid A. Mayer,Amit Verma,Isabella M. Grumbach,Shahab Uddin,Fatima Lekmine,Farhad Ravandi,Beata Majchrzak,Shigeru Fujita,Eleanor N. Fish,Leonidas C. Platanias +9 more
TL;DR: The Rac1/p38 MAPK pathway is activated by IFN-α in BCR-ABL-expressing cells and appears to play a key role in the generation of the growth inhibitory effects of IFn- α in CML cells.
Journal ArticleDOI
Activation of the p70 S6 Kinase and Phosphorylation of the 4E-BP1 Repressor of mRNA Translation by Type I Interferons
Fatima Lekmine,Shahab Uddin,Shahab Uddin,Antonella Sassano,A. Simrit Parmar,Saskia M. Brachmann,Saskia M. Brachmann,Beata Majchrzak,Nahum Sonenberg,Nissim Hay,Eleanor N. Fish,Leonidas C. Platanias +11 more
TL;DR: The data establish that the Type I IFN receptor-activated PI 3′-kinase pathway mediates activation of the p70 S6 kinase and inactivation of 4E-BP1, to regulate mRNA translation and induction of Type IIFN responses.