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Yazan Alsayed
Researcher at University of Illinois at Chicago
Publications - 11
Citations - 986
Yazan Alsayed is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Signal transduction & Phosphorylation. The author has an hindex of 10, co-authored 11 publications receiving 972 citations. Previous affiliations of Yazan Alsayed include University of Illinois at Urbana–Champaign & Veterans Health Administration.
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Journal ArticleDOI
Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons
Shahab Uddin,Beata Majchrzak,Joanna Woodson,Pony Arunkumar,Yazan Alsayed,Richard Pine,Peter R. Young,Eleanor N. Fish,Leonidas C. Platanias +8 more
TL;DR: Evidence is provided that the p38 Map kinase is rapidly phosphorylated and activated during treatment of cells with Type I interferons (IFNα and IFNβ) and plays a critical role ininterferon signaling and interferon-dependent transcriptional regulation.
Journal ArticleDOI
Interferon-α Resistance in a Cutaneous T-Cell Lymphoma Cell Line Is Associated With Lack of STAT1 Expression
Wenn H. Sun,Carlos Pabon,Carlos Pabon,Yazan Alsayed,Yazan Alsayed,Paul P. Huang,Paul P. Huang,Sara Jandeska,Sara Jandeska,Shahab Uddin,Shahab Uddin,Leonidas C. Platanias,Leonidas C. Platanias,Steven T. Rosen,Steven T. Rosen +14 more
TL;DR: The development of an IFN alpha-resistant CTCL cell line (HUT78R), characterized by its ability to proliferate in high concentration of recombinant IFNalpha, which can be used as a model system to study IFN resistance.
Journal ArticleDOI
Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to All-trans-retinoic Acid
Yazan Alsayed,Shahab Uddin,Nadim Mahmud,Fatima Lekmine,Dhananjaya V. Kalvakolanu,Saverio Minucci,Gary M. Bokoch,Leonidas C. Platanias +7 more
TL;DR: Evidence that the p38 MAP kinase pathway is activated in a RA-dependent manner in the NB-4, acute pro-myelocytic leukemia, and the MCF-7, breast carcinoma, cell lines is provided.
Journal ArticleDOI
Engagement of Gab1 and Gab2 in Erythropoietin Signaling
Amittha Wickrema,Shahab Uddin,Arun K. Sharma,Fei Chen,Yazan Alsayed,Sarfraz Ahmad,Stephen T. Sawyer,Gerald Krystal,Taolin Yi,Keigo Nishada,Masahiko Hibi,Toshio Hirano,Leonidas C. Platanias +12 more
TL;DR: Evidence is provided that the recently cloned IRS-related proteins, Gab1 and Gab2, of the Gab family of proteins, are rapidly phosphorylated on tyrosine during erythropoietin treatment of erythroid-responsive cells and provide docking sites for the engagement of the SHP2 phosphatase and the p85 subunit of the phosphatidylinositol 3′-kinase.
Journal ArticleDOI
The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein.
TL;DR: In the IFNα-sensitive U-266 and Daudi cell lines, CrkL interacts via its N terminus SH3 domain with the guanine exchange factor C3G that regulates activation of Rap-1, a small G-protein that exhibits tumor suppressing activity.