B
Beate Leppert
Researcher at University of Bristol
Publications - 21
Citations - 434
Beate Leppert is an academic researcher from University of Bristol. The author has contributed to research in topics: Mendelian randomization & Population. The author has an hindex of 7, co-authored 17 publications receiving 190 citations. Previous affiliations of Beate Leppert include Helmholtz Centre for Environmental Research - UFZ.
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Journal ArticleDOI
Association of maternal neurodevelopmental risk alleles with early-life exposures
Beate Leppert,Alexandra Havdahl,Lucy Riglin,Hannah J. Jones,Hannah J. Jones,Jie Zheng,George Davey Smith,Kate Tilling,Anita Thapar,Ted Reichborn-Kjennerud,Ted Reichborn-Kjennerud,Evie Stergiakouli +11 more
TL;DR: The findings suggest that mothers at high genetic risk for attention-deficit/hyperactivity disorder may also be at increased risk for some adverse pregnancy exposures, and future studies should triangulate evidence from different causally informative approaches.
Journal ArticleDOI
Maternal paraben exposure triggers childhood overweight development
Beate Leppert,Sandra Strunz,Sandra Strunz,Bettina Seiwert,Linda Schlittenbauer,Rita Schlichting,Christiane Pfeiffer,Stefan Röder,Mario Bauer,Michael Borte,Gabriele I. Stangl,Torsten Schöneberg,Angela Schulz,Isabell Karkossa,Ulrike Rolle-Kampczyk,Loreen Thürmann,Loreen Thürmann,Martin von Bergen,Martin von Bergen,Beate I. Escher,Kristin M. Junge,Thorsten Reemtsma,Irina Lehmann,Irina Lehmann,Tobias Polte,Tobias Polte +25 more
TL;DR: It is demonstrated that maternal paraben exposure may contribute to childhood overweight development by an altered neuronal appetite regulation.
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MEST mediates the impact of prenatal bisphenol A exposure on long-term body weight development
Kristin M. Junge,Beate Leppert,Susanne Jahreis,Susanne Jahreis,Dirk K. Wissenbach,Ralph Feltens,Konrad Grützmann,Loreen Thürmann,Loreen Thürmann,Tobias Bauer,Naveed Ishaque,Naveed Ishaque,Matthias Schick,Melanie Bewerunge-Hudler,Stefan Röder,Mario Bauer,Angela Schulz,Michael Borte,Kathrin Landgraf,Antje Körner,Wieland Kiess,Martin von Bergen,Martin von Bergen,Gabriele I. Stangl,Saskia Trump,Roland Eils,Roland Eils,Roland Eils,Tobias Polte,Tobias Polte,Irina Lehmann,Irina Lehmann +31 more
TL;DR: This study provides evidence that MEST mediates the impact of prenatal BPA exposure on long-term body weight development in offspring by triggering adipocyte differentiation.
Journal ArticleDOI
A cross-disorder PRS-pheWAS of 5 major psychiatric disorders in UK Biobank
Beate Leppert,Louise A C Millard,Lucy Riglin,George Davey Smith,Anita Thapar,Kate Tilling,Esther Walton,Esther Walton,Evangelia Stergiakouli +8 more
TL;DR: It is shown that genetic liabilities for five major psychiatric disorders associate with long-term aspects of adult life, including socio-demographic factors, mental and physical health, in individuals from the general population who do not necessarily present with a psychiatric disorder diagnosis.
Journal ArticleDOI
ADHD and depression: investigating a causal explanation.
Lucy Riglin,Beate Leppert,Christina Dardani,Ajay Kumar Thapar,Frances Rice,Michael Conlon O'Donovan,George Davey Smith,Evangelia Stergiakouli,Kate Tilling,Anita Thapar +9 more
TL;DR: It is suggested that ADHD increases the risk of depression later in life and are consistent with a causal effect of ADHD genetic liability on subsequent major depression, however, findings were different for more broadly defined depression.