T
Tobias Polte
Researcher at Helmholtz Centre for Environmental Research - UFZ
Publications - 49
Citations - 2780
Tobias Polte is an academic researcher from Helmholtz Centre for Environmental Research - UFZ. The author has contributed to research in topics: Offspring & Cytoprotection. The author has an hindex of 28, co-authored 48 publications receiving 2432 citations. Previous affiliations of Tobias Polte include Hannover Medical School & Hochschule Hannover.
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Journal ArticleDOI
Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress.
Qing Lin,Sebastian Weis,Guang Yang,Yi-Hao Weng,Rachel Helston,Kimberly Rish,Ann Smith,Jessica Bordner,Tobias Polte,Frank Gaunitz,Phyllis A. Dennery,Phyllis A. Dennery +11 more
TL;DR: It is speculated that nuclear localization of HO-1 protein may serve to up-regulate genes that promote cytoprotection against oxidative stress after exposure to hypoxia and heme or heme/hemopexin.
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IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans.
Uwe Müller,Werner Stenzel,Gabriele Köhler,Christoph Werner,Tobias Polte,Gesine Hansen,Nicole Schütze,Reinhard K. Straubinger,Manfred Blessing,Andrew N. J. McKenzie,Frank Brombacher,Gottfried Alber +11 more
TL;DR: IL-13 contributes to fatal allergic inflammation during C. neoformans infection and was found to induce formation of alternatively activated macrophages expressing arginase-1, macrophage mannose receptor (CD206), and YM1, which led to lung eosinophilia, goblet cell metaplasia and elevated mucus production, and enhanced airway hyperreactivity.
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From the exposome to mechanistic understanding of chemical-induced adverse effects
Beate I. Escher,Jörg Hackermüller,Tobias Polte,Stefan Scholz,Achim Aigner,Rolf Altenburger,Alexander Böhme,Stephanie K. Bopp,Werner Brack,Wibke Busch,Marc Chadeau-Hyam,Adrian Covaci,Adolf Eisenträger,James J. Galligan,Natàlia Garcia-Reyero,Thomas Hartung,Michaela Hein,Gunda Herberth,Annika Jahnke,Jos C. S. Kleinjans,Nils Klüver,Martin Krauss,Marja H. Lamoree,Irina Lehmann,Till Luckenbach,Gary W. Miller,Andrea Müller,David H. Phillips,Thorsten Reemtsma,Ulrike Rolle-Kampczyk,Gerrit Schüürmann,Benno Schwikowski,Yu Mei Tan,Saskia Trump,Susanne Walter-Rohde,John F. Wambaugh +35 more
TL;DR: If mechanistic understanding of the causal links between exposure and adverse effects on human health and the environment can be improved by integrating the exposome approach with the adverse outcome pathway (AOP) concept, this work explores whether this concept can be extended to include broader ecological issues.
Journal ArticleDOI
Heme oxygenase-1 is a cGMP-inducible endothelial protein and mediates the cytoprotective action of nitric oxide.
TL;DR: The results show for the first time that HO-1 is a cGMP-sensitive endothelial gene and establish conclusively a causal relationship betweenHO-1 induction and endothelial protection by the NO/cGMP system.
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Aspirin protects endothelial cells from oxidative stress – possible synergism with vitamin E
TL;DR: Results show that aspirin protects endothelial cells from oxidative stress possibly via binding or chelation of free cytosolic iron, and a combination of aspirin and vitamin E might be useful for the prevention of endothelial injury in cardiovascular disease, e.g. during atherogenesis.