A
Alexandra Havdahl
Researcher at Norwegian Institute of Public Health
Publications - 94
Citations - 1186
Alexandra Havdahl is an academic researcher from Norwegian Institute of Public Health. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 47 publications receiving 456 citations. Previous affiliations of Alexandra Havdahl include University of Bristol & University of Oslo.
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Journal ArticleDOI
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
Ben Michael Brumpton,Ben Michael Brumpton,Eleanor Sanderson,Karl Heilbron,Fernando Pires Hartwig,Fernando Pires Hartwig,Sean Harrison,Gunnhild Åberge Vie,Yoonsu Cho,Laura D Howe,Amanda Hughes,Dorret I. Boomsma,Alexandra Havdahl,Alexandra Havdahl,John L. Hopper,Michael C. Neale,Michel G. Nivard,Nancy L. Pedersen,Chandra A. Reynolds,Elliot M. Tucker-Drob,Andrew D. Grotzinger,Laurence J. Howe,Tim T Morris,Shuai Li,Shuai Li,Adam Auton,Frank Windmeijer,Wei-Min Chen,Johan Håkon Bjørngaard,Johan Håkon Bjørngaard,Kristian Hveem,Cristen J. Willer,David M. Evans,David M. Evans,Jaakko Kaprio,George Davey Smith,Bjørn Olav Åsvold,Gibran Hemani,Neil M Davies,Neil M Davies +39 more
TL;DR: Methods for within-family Mendelian randomization analyses are described and simulation studies are used to show that family-based analyses can reduce such biases in Mendelians randomization through within- family studies.
Journal ArticleDOI
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Laurence J. Howe,Michel G. Nivard,Tim T Morris,Ailin Falkmo Hansen,Humaira Rasheed,Yoonsu Cho,Geetha Chittoor,Rafael Ahlskog,Penelope A. Lind,Teemu Palviainen,Matthijs D. van der Zee,Rosa Cheesman,Massimo Mangino,Yunzhang Wang,Shuai Li,Lucija Klaric,Scott M. Ratliff,Lawrence F. Bielak,Marianne Nygaard,Alexandros Giannelis,Emily A. Willoughby,Chandra A. Reynolds,Jared V. Balbona,Ole A. Andreassen,Helga Ask,Aris Baras,Christopher R. Bauer,Dorret I. Boomsma,Archie Campbell,Harry Campbell,Zhengming Chen,Paraskevi Christofidou,Elizabeth Corfield,Christina C. Dahm,Deepika Dokuru,Luke M. Evans,Eco J. C. de Geus,Sudheer Giddaluru,Scott D. Gordon,K. Paige Harden,WD Hill,Shona M. Kerr,Yongkang Kim,Hyeokmoon Kweon,Antti Latvala,D. A. Lawlor,Liming Li,Kuang Lin,Per Magnus,Patrik K. E. Magnusson,Travis T. Mallard,Pekka Martikainen,Melinda Mills,Pål R. Njølstad,John D. Overton,Nancy L. Pedersen,David J. Porteous,Jeffrey S. Reid,Karri Silventoinen,Melissa C. Southey,Camilla Stoltenberg,Elliot M. Tucker-Drob,M. Wright,John K. Hewitt,Matthew C. Keller,Michael C. Stallings,James J. Lee,Kaare Christensen,Sharon L.R. Kardia,Patricia A. Peyser,Jennifer A. Smith,James F. Wilson,John L. Hopper,Sara Hägg,Tim D. Spector,Jean-Baptiste Pingault,Robert Plomin,Alexandra Havdahl,Meike Bartels,Nicholas G. Martin,Sven Oskarsson,Anne E. Justice,Iona Y. Millwood,Kristian Hveem,Ø. Naess,Cristen J. Willer,Bjørn Olav Åsvold,Philipp Koellinger,Jaakko Kaprio,Sarah E. Medland,Robin G. Walters,Daniel J. Benjamin,Patrick Turley,David M. Evans,George Davey Smith,Caroline Hayward,Ben Michael Brumpton,Gibran Hemani,Neil M Davies +98 more
TL;DR: In this paper , the authors combined data from 178,086 siblings from 19 cohorts to generate population (between-family) and within-sibship (within family) estimates for 25 phenotypes.
Journal ArticleDOI
Within family Mendelian randomization studies.
Neil M Davies,Laurence J. Howe,Ben Michael Brumpton,Ben Michael Brumpton,Alexandra Havdahl,Alexandra Havdahl,David M. Evans,David M. Evans,George Davey Smith +8 more
TL;DR: It is explained how studies of related individuals such as sibling pairs or parent-offspring trios can be used to overcome some of these sources of bias, to provide potentially more reliable evidence regarding causal processes.
Posted ContentDOI
Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases
Ben Michael Brumpton,Ben Michael Brumpton,Eleanor Sanderson,Fernando Pires Hartwig,Fernando Pires Hartwig,Sean Harrison,Gunnhild Åberge Vie,Yoonsu Cho,Laura D Howe,Amanda Hughes,Dorret I. Boomsma,Alexandra Havdahl,Alexandra Havdahl,John L. Hopper,Michael C. Neale,Michel G. Nivard,Nancy L. Pedersen,Chandra A. Reynolds,Elliot M. Tucker-Drob,Andrew D. Grotzinger,Laurence J. Howe,Tim T Morris,Shuai Li,Shuai Li,Wei-Min Chen,Johan Håkon Bjørngaard,Kristian Hveem,Cristen J. Willer,David M. Evans,David M. Evans,Jaakko Kaprio,George Davey Smith,Bjørn Olav Åsvold,Gibran Hemani,Neil M Davies +34 more
TL;DR: Differences between population-based and within-family based MR estimates are found, indicating the importance of controlling for family effects and population structure in Mendelian randomization studies.
Journal ArticleDOI
Association of maternal neurodevelopmental risk alleles with early-life exposures
Beate Leppert,Alexandra Havdahl,Lucy Riglin,Hannah J. Jones,Hannah J. Jones,Jie Zheng,George Davey Smith,Kate Tilling,Anita Thapar,Ted Reichborn-Kjennerud,Ted Reichborn-Kjennerud,Evie Stergiakouli +11 more
TL;DR: The findings suggest that mothers at high genetic risk for attention-deficit/hyperactivity disorder may also be at increased risk for some adverse pregnancy exposures, and future studies should triangulate evidence from different causally informative approaches.