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Beatrice Nickel
Researcher at Swiss Tropical and Public Health Institute
Publications - 34
Citations - 508
Beatrice Nickel is an academic researcher from Swiss Tropical and Public Health Institute. The author has contributed to research in topics: Antigen & Schistosomiasis. The author has an hindex of 11, co-authored 29 publications receiving 380 citations. Previous affiliations of Beatrice Nickel include University Medical Center Freiburg & University of Basel.
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Journal ArticleDOI
Safety, tolerability and immunogenicity of new formulations of the Plasmodium falciparum malaria peptide vaccine SPf66 combined with the immunological adjuvant QS-21.
Oscar Kashala,Roberto Amador,M. Valero,Alberto Moreno,Arnoldo Barbosa,Beatrice Nickel,Claudia Daubenberger,Fanny Guzmán,Gerd Pluschke,Manuel E. Patarroyo +9 more
TL;DR: It is demonstrated that the use of QS-21 can substantially enhance the immunogenicity of peptide vaccines, such as SPf66, which has been found to induce only CD4+ T cell response, and exhibited the potential to also elicit SPf 66-specific CD8+ responses.
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Real-time PCR for detection of Strongyloides stercoralis in human stool samples from Côte d'Ivoire : diagnostic accuracy, inter-laboratory comparison and patterns of hookworm co-infection
Sören L. Becker,Sören L. Becker,Sören L. Becker,Nivetha Piraisoody,Stefanie Kramme,Stefanie Kramme,Hanspeter Marti,Hanspeter Marti,Kigbafori D. Silué,Marcus Panning,Beatrice Nickel,Beatrice Nickel,Winfried V. Kern,Mathias Herrmann,Christoph Hatz,Christoph Hatz,Christoph Hatz,Eliézer K. N’Goran,Jürg Utzinger,Jürg Utzinger,Lutz von Müller +20 more
TL;DR: A combination of real-time PCR and stool microscopy shows high accuracy for S. stercoralis diagnosis, and PCR may also enhance specificity by reducing microscopic misdiagnosis of morphologically similar helminth larvae in settings where both helminths species co-exist.
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Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia
Youthanavanh Vonghachack,Youthanavanh Vonghachack,Youthanavanh Vonghachack,Somphou Sayasone,Virak Khieu,Robert Bergquist,Govert J. van Dam,Pytsje T. Hoekstra,Paul L. A. M. Corstjens,Beatrice Nickel,Beatrice Nickel,Hanspeter Marti,Hanspeter Marti,Jürg Utzinger,Jürg Utzinger,Sinuon Muth,Peter Odermatt,Peter Odermatt +17 more
TL;DR: The CCA, CAA and ELISA results showed substantially higher prevalence estimates for S. mekongi compared to Kato-Katz thick smears, showing the pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised.
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Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania
Patrizia Amelio,Damien Portevin,Klaus Reither,Klaus Reither,Francis Apolinary Mhimbira,Maxmillian Mpina,Anneth Tumbo,Beatrice Nickel,Beatrice Nickel,Hanspeter Marti,Hanspeter Marti,Stefanie Knopp,Stefanie Knopp,Song Ding,Adam Penn-Nicholson,Fatoumatta Darboe,Khalid Ohmiti,Thomas J. Scriba,Giuseppe Pantaleo,Claudia Daubenberger,Claudia Daubenberger,Matthieu Perreau +21 more
TL;DR: Results indicate that the generation of Mtb-specific CD4 and CD8 T cell responses may be substantially influenced by environmental factors in vivo, which may have major impact in the identification of immune biomarkers of disease status and correlates of protection.
Journal ArticleDOI
Accuracy of Diagnostic Tests for Schistosoma mansoni Infection in Asymptomatic Eritrean Refugees: Serology and Point-of-Care Circulating Cathodic Antigen Against Stool Microscopy.
Afona Chernet,Afona Chernet,Kerstin Kling,Kerstin Kling,Véronique Sydow,Véronique Sydow,Esther Kuenzli,Esther Kuenzli,Christoph Hatz,Christoph Hatz,Jürg Utzinger,Jürg Utzinger,Lisette van Lieshout,Hanspeter Marti,Hanspeter Marti,Beatrice Nickel,Beatrice Nickel,Niklaus Daniel Labhardt,Niklaus Daniel Labhardt,Andreas Neumayr,Andreas Neumayr +20 more
TL;DR: The combination of serology plus urine POC-CCA testing appears to be the most sensitive screening option for asymptomatic S. mansoni infection in Eritrean refugees, compared with stool sedimentation microscopy.