G
Gerd Pluschke
Researcher at Swiss Tropical and Public Health Institute
Publications - 239
Citations - 7863
Gerd Pluschke is an academic researcher from Swiss Tropical and Public Health Institute. The author has contributed to research in topics: Mycobacterium ulcerans & Buruli ulcer. The author has an hindex of 49, co-authored 229 publications receiving 7166 citations. Previous affiliations of Gerd Pluschke include University of Basel & Novartis.
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Journal ArticleDOI
A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites.
Olivier Silvie,Jean-François Franetich,Stéphanie Charrin,Markus S. Mueller,Anthony Siau,Myriam Bodescot,Eric Rubinstein,Laurent Hannoun,Yupin Charoenvit,Clemens H. M. Kocken,Alan W. Thomas,Geert-Jan van Gemert,Robert W. Sauerwein,Michael J. Blackman,Robin F. Anders,Gerd Pluschke,Dominique Mazier +16 more
TL;DR: Investigation of the expression and function of another microneme protein recently identified in Plasmodium falciparum sporozoites, apical membrane antigen 1 (AMA-1), finds that interfering with sporozoite proteolytic processing may constitute a valuable strategy to prevent hepatocyte infection.
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Buruli Ulcer (M. ulcerans Infection): New Insights, New Hope for Disease Control
Paul D R Johnson,Timothy P. Stinear,Pamela L. C. Small,Gerd Pluschke,Richard W. Merritt,Françoise Portaels,Kris Huygen,John A. Hayman,Kingsley Asiedu +8 more
TL;DR: Buruli ulcer is a disease of skin and soft tissue caused by Mycobacterium ulcerans that can leave affected people scarred and disabled.
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An Outbreak of Serotype 1 Streptococcus pneumoniae Meningitis in Northern Ghana with Features That Are Characteristic of Neisseria meningitidis Meningitis Epidemics
Julia Leimkugel,Abudulai Adams Forgor,Sebastien Gagneux,Valentin Pflüger,Christian Flierl,Elizabeth Awine,Martin Naegeli,Jean-Pierre Dangy,Thomas B. Smith,Abraham Hodgson,Gerd Pluschke +10 more
TL;DR: The results suggest that this lineage of pneumococcal meningitis might have the potential to cause an epidemic, and mass vaccination with a less complex conjugate vaccine that targets hypervirulent serotypes should be considered.
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Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1 Receptors
Mark Bauer,Mark Bauer,Andrea Chicca,Marco Tamborrini,David Eisen,Raissa Lerner,Beat Lutz,Oliver Poetz,Gerd Pluschke,Jürg Gertsch +9 more
TL;DR: Pepcans are the first endogenous allosteric modulators identified for CB1 receptors and could play an important physiological role in modulating endocannabinoid signaling.
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On the origin of mycobacterium ulcerans, the causative agent of buruli ulcer
Ken Doig,Kathryn E. Holt,Janet A. M. Fyfe,Caroline J. Lavender,Miriam Eddyani,Françoise Portaels,Dorothy Yeboah-Manu,Gerd Pluschke,Gerd Pluschke,Torsten Seemann,Timothy P. Stinear +10 more
TL;DR: A high-resolution phylogeny based on genome-wide single nucleotide polymorphisms (SNPs) showed that M. ulcerans and all mycolactone-producing mycobacteria are specialized variants of a common Mycobacterium marinum progenitor that have adapted to live in restricted environments.