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Béatrice Poirier-Beaudouin
Researcher at Pasteur Institute
Publications - 6
Citations - 76
Béatrice Poirier-Beaudouin is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 4, co-authored 6 publications receiving 37 citations.
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Journal ArticleDOI
HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry
Audrey Paoletti,Awatef Allouch,Marina Caillet,Marina Caillet,Héla Saïdi,Frédéric Subra,Roberta Nardacci,Qiuji Wu,Zeinaf Muradova,Laurent Voisin,Syed Qasim Raza,Frédéric Law,Maxime Thoreau,Haithem Dakhli,Olivier Delelis,Béatrice Poirier-Beaudouin,Nathalie Dereuddre-Bosquet,Nathalie Dereuddre-Bosquet,Roger Le Grand,Roger Le Grand,Olivier Lambotte,Asier Sáez-Cirión,Gianfranco Pancino,David M. Ojcius,David M. Ojcius,Eric Solary,Eric Deutsch,Eric Deutsch,Mauro Piacentini,Marie-Lise Gougeon,Guido Kroemer,Jean-Luc Perfettini +31 more
TL;DR: It is found that NLRP3 acts as an inhibitory factor of viral entry that represses F-actin remodeling and is permissive for PYK2 phosphorylation and subsequent F- actin polymerization, which is required for the entry of HIV-1 into host cells.
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Erratum to 'HMGB1/anti-HMGB1 antibodies define a molecular signature of early stages of HIV-Associated Neurocognitive Disorders (HAND)'.
Marie-Lise Gougeon,Béatrice Poirier-Beaudouin,Jacques Durant,Christine Lebrun-Frenay,Héla Saïdi,Valérie Seffer,Michel Ticchioni,Stéphane Chanalet,Hélène Carsenti,Alexandra Harvey-Langton,M. Laffon,Jacqueline Cottalorda,Christian Pradier,Pierre Dellamonica,Matteo Vassallo +14 more
TL;DR: This research presents a novel probabilistic approach to estimating the response of the immune system to laser-spot assisted, 3D image analysis of EMTs.
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Suppression by thimerosal of ex-vivo CD4+ T cell response to influenza vaccine and induction of apoptosis in primary memory T cells.
Emily Loison,Béatrice Poirier-Beaudouin,Valérie Seffer,Audrey Paoletti,Vered Abitbol,Eric Tartour,Odile Launay,Marie-Lise Gougeon +7 more
TL;DR: Results underline the proapoptotic effect of thimerosal on primary human lymphocytes at concentrations 100 times less to those contained in the multidose vaccine, and reveal the inhibitory effect of this preservative on T-cell proliferation and functions at nanomolar concentrations.
Journal ArticleDOI
Zika Virus Inhibits IFN-α Response by Human Plasmacytoid Dendritic Cells and Induces NS1-Dependent Triggering of CD303 (BDCA-2) Signaling
Sandra Bos,Sandra Bos,Béatrice Poirier-Beaudouin,Valérie Seffer,Maria Manich,Cartini Mardi,Philippe Desprès,Gilles Gadea,Marie-Lise Gougeon +8 more
TL;DR: It is shown that ZIKV developed a strategy to inhibit the IFN-α response in primary human pDCs likely mediated through NS1-dependent CD303 signaling, thus suggesting a new mechanism of immune evasion.
Journal ArticleDOI
Cell-Mediated Immunity to NAGLU Transgene Following Intracerebral Gene Therapy in Children With Mucopolysaccharidosis Type IIIB Syndrome.
Marie-Lise Gougeon,Béatrice Poirier-Beaudouin,Jérôme Ausseil,Michel Zerah,Cecile Artaud,Jean-Michel Heard,Kumaran Deiva,Marc Tardieu +7 more
TL;DR: In this paper, the authors performed a comprehensive analysis of cellular immunity and cytokine patterns generated against the therapeutic enzyme in the four treated children over 5.5 years of follow-up, and found that gene therapy did not trigger neuroinflammation, evaluated through the expression of cytokines and chemokines in patients' CSF.