Bence Bruncsics

TL;DR: A mathematical model is presented that accurately simulates binding kinetics and equilibria of multivalent protein–protein interactions as a function of the kinetics of monomer–monomer binding, the structure and topology of the multidomain interacting partners, and the valency of each partner.

TL;DR: Antibody-lectin chimeras (AbLecs) as discussed by the authors are bispecific antibody-like molecules comprising a tumor-targeting arm as well as a lectin "decoy receptor" domain that directly binds tumor glycans and blocks their ability to engage lectin receptors on immune cells.

TL;DR: MVsim as discussed by the authors is an application suite built around a configurational network model of multivalency to facilitate the quantification, design, and mechanistic evaluation of multivalent binding phenomena through a simple graphical user interface.

TL;DR: It is found that the PGS is significantly associated with highest educational level attained as well as the number of years in education in a sample of Hungarian volunteers, providing evidence that polygenic scores for educational attainment are valid in diverse European populations.

TL;DR: This article used a Hungarian sample of healthy volunteers to assess the validity of the most recent educational attainment polygenic score in a population culturally and genetically different from the one used in GWAS discovery, as well as changes in PGS heritability over time.