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Benjamin Boese
Researcher at Hoffmann-La Roche
Publications - 11
Citations - 1045
Benjamin Boese is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Aptamer & Exome sequencing. The author has an hindex of 8, co-authored 11 publications receiving 995 citations. Previous affiliations of Benjamin Boese include McNeese State University & City College of New York.
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Journal ArticleDOI
Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria
TL;DR: This work has identified a class of riboswitches that selectively recognizes guanine and becomes saturated at concentrations as low as 5 nM, and it is now apparent that ribosWitches contribute to the regulation of numerous fundamental metabolic pathways in certain bacteria.
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Exome Sequencing of a Multigenerational Human Pedigree
Dale J. Hedges,Dan Burges,Eric Powell,Cherylyn Almonte,Jia-Jia Huang,Stuart Young,Benjamin Boese,Michael A. Schmidt,Margaret A. Pericak-Vance,Eden R. Martin,Xinmin Zhang,Timothy T. Harkins,Stephan Züchner +12 more
TL;DR: This work evaluated a 2.1 M feature human exome capture array on eight individuals from a three-generation family pedigree and proposed an advantageous genotype calling strategy for low covered targets that empirically determines cut-off thresholds at a given coverage depth based on existing genotype data.
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DNA Sequence Capture and Enrichment by Microarray Followed by Next-Generation Sequencing for Targeted Resequencing: Neurofibromatosis Type 1 Gene as a Model
TL;DR: A clinically relevant complex genomic target was used to evaluate a microarray-based sample-enrichment process and an NGS instrument for clinical resequencing purposes and allowed a systematic data-analysis strategy and algorithm to fit potential clinical applications to be developed.
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Insights into the evolution of Darwin’s finches from comparative analysis of the Geospiza magnirostris genome sequence
Chris M Rands,Aaron E. Darling,Matthew K. Fujita,Matthew K. Fujita,Lesheng Kong,Matthew T. Webster,Céline Clabaut,Richard D. Emes,Andreas Heger,Stephen Meader,Michael Brent Hawkins,Michael B. Eisen,Clotilde Teiling,Jason P. Affourtit,Jason P. Affourtit,Benjamin Boese,Peter R. Grant,Barbara Rosemary Grant,Jonathan A. Eisen,Arkhat Abzhanov,Chris P. Ponting +20 more
TL;DR: Genic evolutionary rate comparisons indicate that similar selective pressures acted along the G. magnirostris and zebra finch lineages suggesting that historical effective population size values have been similar in both lineages.
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In vitro selection and characterization of cellulose-binding DNA aptamers
Benjamin Boese,Ronald R. Breaker +1 more
TL;DR: New DNA aptamers that bind cellulose to provide a module for immobilizing DNAs and an allosteric aptamer construct was engineered that exhibits ATP-mediated cellulose binding during paper chromatography.