M
Michael A. Schmidt
Researcher at University of Miami
Publications - 26
Citations - 1423
Michael A. Schmidt is an academic researcher from University of Miami. The author has contributed to research in topics: Genome-wide association study & Exome sequencing. The author has an hindex of 14, co-authored 26 publications receiving 1074 citations. Previous affiliations of Michael A. Schmidt include John P. Hussman Institute for Human Genomics.
Papers
More filters
Journal ArticleDOI
Exome sequencing of extended families with autism reveals genes shared across neurodevelopmental and neuropsychiatric disorders
Holly N. Cukier,Nicole Dueker,Susan Slifer,Joycelyn M. Lee,Patrice L. Whitehead,Eminisha Lalanne,Natalia Leyva,Ioanna Konidari,Ryan C Gentry,William Hulme,Derek J. Van Booven,Vera Mayo,Natalia K. Hofmann,Michael A. Schmidt,Eden R. Martin,Jonathan L. Haines,Michael L. Cuccaro,John R. Gilbert,Margaret A. Pericak-Vance +18 more
TL;DR: This work has identified novel DNA variations related to ASD, demonstrated that exome sequencing in extended families is a powerful tool for ASD candidate gene discovery, and provided further evidence of an underlying genetic component to a wide range of neurodevelopmental and neuropsychiatric diseases.
Journal ArticleDOI
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation
Joshua C. Bis,Xueqiu Jian,Brian W. Kunkle,Yuning Chen,Kara L. Hamilton-Nelson,William S. Bush,William J Salerno,Daniel Lancour,Yiyi Ma,Alan E. Renton,Edoardo Marcora,John J. Farrell,Yi Zhao,Liming Qu,Shahzad Ahmad,Najaf Amin,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Gary W. Beecham,Jennifer E. Below,Dominique Campion,Laura B. Cantwell,Camille Charbonnier,Jaeyoon Chung,Paul K. Crane,Carlos Cruchaga,L. Adrienne Cupples,Jean-François Dartigues,Stéphanie Debette,Jean-François Deleuze,Lucinda Fulton,Stacey Gabriel,Emmanuelle Génin,Richard A. Gibbs,Alison Goate,Benjamin Grenier-Boley,Namrata Gupta,Jonathan L. Haines,Aki S. Havulinna,Aki S. Havulinna,Seppo Helisalmi,Mikko Hiltunen,Daniel P. Howrigan,Daniel P. Howrigan,M. Arfan Ikram,Jaakko Kaprio,Jan Konrad,Amanda B. Kuzma,Eric S. Lander,Mark Lathrop,Terho Lehtimäki,Honghuang Lin,Kari Mattila,Richard Mayeux,Donna M. Muzny,Waleed Nasser,Benjamin M. Neale,Benjamin M. Neale,Kwangsik Nho,Gaël Nicolas,Devanshi Patel,Margaret A. Pericak-Vance,Markus Perola,Markus Perola,Markus Perola,Bruce M. Psaty,Olivier Quenez,Farid Rajabli,Richard Redon,Christiane Reitz,Anne M. Remes,Anne M. Remes,Veikko Salomaa,Chloé Sarnowski,Helena Schmidt,Michael A. Schmidt,Reinhold Schmidt,Hilkka Soininen,Timothy A. Thornton,Giuseppe Tosto,Christophe Tzourio,Sven J. van der Lee,Cornelia M. van Duijn,Otto Valladares,Badri N. Vardarajan,Li-San Wang,Weixin Wang,Ellen M. Wijsman,Richard K. Wilson,Daniela Witten,Kim C. Worley,Xiaoling Zhang,Alzheimer’s Disease Sequencing,Alzheimer’s Disease Sequencing,Alzheimer’s Disease Sequencing,Céline Bellenguez,Jean-Charles Lambert,Mitja I. Kurki,Mitja I. Kurki,Mitja I. Kurki,Aarno Palotie,Aarno Palotie,Aarno Palotie,Mark J. Daly,Mark J. Daly,Mark J. Daly,Eric Boerwinkle,Eric Boerwinkle,Kathryn L. Lunetta,Anita L. DeStefano,Josée Dupuis,Eden R. Martin,Gerard D. Schellenberg,Sudha Seshadri,Sudha Seshadri,Adam C. Naj,Myriam Fornage,Lindsay A. Farrer +118 more
TL;DR: The Alzheimer’s Disease Sequencing Project undertook whole exome sequencing in 5,740 late-onset Alzheimer disease cases and 5,096 cognitively normal controls primarily of European ancestry, identifying novel and predicted functional genetic variants in genes previously associated with AD.
Journal ArticleDOI
Evaluation of Copy Number Variations Reveals Novel Candidate Genes in Autism Spectrum Disorder Associated Pathways
Anthony J. Griswold,Deqiong Ma,Holly N. Cukier,Laura D. Nations,Michael A. Schmidt,Ren-Hua Chung,James M. Jaworski,Daria Salyakina,Ioanna Konidari,Patrice L. Whitehead,Harry H. Wright,Ruth K. Abramson,Scott M. Williams,Ramkumar Menon,Eden R. Martin,Jonathan L. Haines,John R. Gilbert,Michael L. Cuccaro,Margaret A. Pericak-Vance +18 more
TL;DR: A significantly higher burden in the number and size of deletions is identified, and evidence of genetic overlap between ASDs and other neurodevelopmental and neuropsychiatric diseases is found, finding a few of the missing pieces of ASD heritability and lead to discovering novel etiological mechanisms.
Journal ArticleDOI
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis
Brian W. Kunkle,Michael A. Schmidt,Hans-Ulrich Klein,Adam C. Naj,Kara L. Hamilton-Nelson,Eric B. Larson,Eric B. Larson,Denis A. Evans,Phil De Jager,Paul K. Crane,Joe D. Buxbaum,Nilufer Ertekin-Taner,Lisa L. Barnes,M. Daniele Fallin,Jennifer J. Manly,Rodney C.P. Go,Thomas O. Obisesan,M. Ilyas Kamboh,David A. Bennett,Kathleen S. Hall,Alison Goate,Tatiana Foroud,Eden R. Martin,Li Sao Wang,Goldie S. Byrd,Lindsay A. Farrer,Jonathan L. Haines,Gerard D. Schellenberg,Richard Mayeux,Margaret A. Pericak-Vance,Christiane Reitz,Neill R. Graff-Radford,Izri Martinez,Temitope Ayodele,Mark W. Logue,Mark W. Logue,Laura B. Cantwell,Melissa Jean-Francois,Amanda B. Kuzma,Larry D. Adams,Jeffery M. Vance,Michael L. Cuccaro,Jaeyoon Chung,Jesse Mez,Kathryn L. Lunetta,Gyungah Jun,Oscar L. Lopez,Hugh C. Hendrie,Eric M. Reiman,Neil W. Kowall,James B. Leverenz,Scott A. Small,Allan I. Levey,Todd E. Golde,Andrew J. Saykin,Takiyah D. Starks,Marilyn S. Albert,Bradley T. Hyman,Ronald C. Petersen,Mary Sano,Thomas Wisniewski,Robert Vassar,Jeffrey Kaye,Victor W. Henderson,Charles DeCarli,Frank M. LaFerla,James B. Brewer,Bruce L. Miller,Russell H. Swerdlow,Linda J. Van Eldik,Henry L. Paulson,John Q. Trojanowski,Helena C. Chui,Roger N. Rosenberg,Suzanne Craft,Thomas J. Grabowski,Sanjay Asthana,John C. Morris,Stephen M. Strittmatter,Walter A. Kukull +79 more
TL;DR: Pathway analyses strongly support the notion that immunity, lipid processing, and intracellular trafficking pathways underlying Alzheimer disease in African American individuals overlap with those observed in non-Hispanic White individuals.
Journal ArticleDOI
SeqEM: an adaptive genotype-calling approach for next-generation sequencing studies
Eden R. Martin,Daniel D. Kinnamon,Michael A. Schmidt,Eric Powell,Stephan Züchner,Richard W Morris +5 more
TL;DR: The proposed genotype-calling algorithm, which is called SeqEM, applies the well-known Expectation-Maximization algorithm to an appropriate likelihood for a sample of unrelated individuals with next-generation sequence data, leveraging information from the sample to estimate genotype probabilities and the nucleotide-read error rate.