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Benjamin D. Umans
Researcher at Harvard University
Publications - 14
Citations - 1338
Benjamin D. Umans is an academic researcher from Harvard University. The author has contributed to research in topics: Bacterial outer membrane & Vibrio cholerae. The author has an hindex of 10, co-authored 14 publications receiving 832 citations. Previous affiliations of Benjamin D. Umans include University of Cambridge & University of Chicago.
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Journal ArticleDOI
Sensory Neurons that Detect Stretch and Nutrients in the Digestive System
Erika K. Williams,Rui B. Chang,David E. Strochlic,Benjamin D. Umans,Bradford B. Lowell,Stephen D. Liberles +5 more
TL;DR: The roles of vagal afferents in mediating particular gut hormone responses are clarified and genetic control over gut-to-brain neurons provides a molecular framework for understanding neural control of gastrointestinal physiology.
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Vagal Sensory Neuron Subtypes that Differentially Control Breathing.
TL;DR: The vagus nerve contains intermingled sensory neurons constituting genetically definable labeled lines with different anatomical connections and physiological roles, which reveal that these neurons densely innervate the lung and send long-range projections to different brainstem targets.
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Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia
Pankaj Baral,Benjamin D. Umans,Lu Li,Antonia Wallrapp,Meghna Bist,Talia Kirschbaum,Yibing Wei,Yan Zhou,Vijay K. Kuchroo,Patrick R. Burkett,Bryan G. Yipp,Stephen D. Liberles,Isaac M. Chiu +12 more
TL;DR: It is found that TRPV1+ nociceptors suppressed protective immunity against lethal Staphylococcus aureus pneumonia and targeting neuroimmunological signaling increased survival, cytokine induction, and lung bacterial clearance.
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Where Are the Disease-Associated eQTLs?
TL;DR: It is discussed new technologies that can extend the standard regulatory mapping framework to more diverse, disease-relevant cell types and states and suggest an alternative strategy drawing on the dynamic and highly context-specific nature of gene regulation.
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An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents
TL;DR: Rare throat-innervating neurons are discovered that guard the airways against assault and provide mechanistic insights into airway defense and a general molecular/genetic roadmap for internal organ sensation by the vagus nerve.