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Benjamin M. Hutchins
Researcher at Scripps Research Institute
Publications - 13
Citations - 1153
Benjamin M. Hutchins is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Quantum dot & Amino acid. The author has an hindex of 10, co-authored 13 publications receiving 1047 citations. Previous affiliations of Benjamin M. Hutchins include Skidmore College & Pennsylvania State University.
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Journal ArticleDOI
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids
Jun Y. Axup,Krishna M. Bajjuri,Melissa Ritland,Benjamin M. Hutchins,Chan Hyuk Kim,Stephanie A. Kazane,Rajkumar Halder,Jane Forsyth,Antonio F. Santidrian,Karin Stafin,Yingchun Lu,Hon Tran,Aaron J. Seller,Sandra Biroc,Aga Szydlik,Jason Pinkstaff,Feng Tian,Subhash C. Sinha,Brunhilde Felding-Habermann,Vaughn V. Smider,Peter G. Schultz +20 more
TL;DR: Genetically encoded unnatural amino acids with orthogonal chemical reactivity are used to synthesize homogeneous ADCs with precise control of conjugation site and stoichiometry to facilitate the optimization of ADCs for a host of therapeutic uses.
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Synthesis of bispecific antibodies using genetically encoded unnatural amino acids.
Chan Hyuk Kim,Jun Y. Axup,Anna Dubrovska,Stephanie A. Kazane,Benjamin M. Hutchins,Erik D. Wold,Vaughn V. Smider,Peter G. Schultz +7 more
TL;DR: An anti-HER2/anti-CD3 bispecific antibody is synthesized, which efficiently cross-linked HER2+ cells and CD3+ cells, and in vitro effector-cell mediated cytotoxicity was observed at picomolar concentrations.
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Self-assembled antibody multimers through peptide nucleic acid conjugation.
Stephanie A. Kazane,Jun Y. Axup,Chan Hyuk Kim,Mihai Ciobanu,Erik D. Wold,Sofia Barluenga,Benjamin M. Hutchins,Peter G. Schultz,Nicolas Winssinger,Vaughn V. Smider +9 more
TL;DR: It is shown that unnatural amino acids with orthogonal chemical reactivity can be used to generate site-specific antibody-oligonucleotide conjugates that recruit cytotoxic T lymphocytes to Her2 and CD20 positive cancer cells and multimeric antibody fragments with enhanced activity.
Journal ArticleDOI
Site-specific coupling and sterically controlled formation of multimeric antibody fab fragments with unnatural amino acids.
Benjamin M. Hutchins,Stephanie A. Kazane,Karin Staflin,Jane Forsyth,Brunhilde Felding-Habermann,Peter G. Schultz,Vaughn V. Smider +6 more
TL;DR: An encoded unnatural amino acid produces a chemical "handle" by which immunoconjugates and multimers can be engineered, and assembled Fab multimers differentially attenuate Her2 phosphorylation in breast cancer cells that overexpress the Her2 receptor.
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Directing Transport of CoFe2O4‐Functionalized Microtubules with Magnetic Fields
TL;DR: This work shows that by selectively functionalizing microtubule segments with 20-nm CoFe2O4 magnetic nanoparticles, external magnetic fields can be used to control the transport direction of gliding microtubules without affecting their transport speed.