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Benjamin M. Laitman
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 45
Citations - 982
Benjamin M. Laitman is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Oligodendrocyte & Medicine. The author has an hindex of 11, co-authored 41 publications receiving 696 citations. Previous affiliations of Benjamin M. Laitman include University of Pennsylvania & Mount Sinai Hospital.
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Journal ArticleDOI
Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens
Jian Feng,Matthew Wilkinson,Xiaochuan Liu,Immanuel Purushothaman,Deveroux Ferguson,Vincent Vialou,Ian Maze,Ning-Yi Shao,Pamela J. Kennedy,Ja Wook Koo,Caroline Dias,Benjamin M. Laitman,Victoria Stockman,Quincey LaPlant,Michael E. Cahill,Eric J. Nestler,Li Shen +16 more
TL;DR: This delineation of the cocaine-induced epigenome in the nucleus accumbens reveals several novel modes of regulation by which cocaine alters the brain, and serves as a template for the analysis of other systems to reveal new transcriptional and epigenetic mechanisms of neuronal regulation.
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Role of Tet1 and 5-hydroxymethylcytosine in cocaine action
Jian Feng,Ning-Yi Shao,Keith E. Szulwach,Vincent Vialou,Vincent Vialou,Jimmy Huynh,Chun Zhong,Thuc Le,Deveroux Ferguson,Michael E. Cahill,Yujing Li,Ja Wook Koo,Efrain Ribeiro,Benoit Labonté,Benjamin M. Laitman,David Estey,Victoria Stockman,Pamela J. Kennedy,Thomas Couroussé,Isaac Mensah,Gustavo Turecki,Kym F. Faull,Guo Li Ming,Hongjun Song,Guoping Fan,Patrizia Casaccia,Li Shen,Peng Jin,Eric J. Nestler +28 more
TL;DR: It is found that ten-eleven translocation protein 1 (TET1) was downregulated in mouse nucleus accumbens (NAc) by repeated cocaine administration, which enhanced behavioral responses to cocaine, and new insight is provided into how 5hmC regulates transcription in brain in vivo.
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Student Perspectives on the "Step 1 Climate" in Preclinical Medical Education.
David R. Chen,Kelsey C. Priest,Jason N Batten,Ligia E Fragoso,Bradley I. Reinfeld,Benjamin M. Laitman +5 more
TL;DR: Students from various institutions across the country draw on their shared experiences to argue that the emphasis on Step 1 for residency selection has fundamentally altered the preclinical learning environment, creating a “Step 1 climate” and urge a national conversation on the elimination of reporting Step 1 numeric scores.
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Mental health among otolaryngology resident and attending physicians during the COVID-19 pandemic: National study.
Alyssa M. Civantos,Yasmeen M. Byrnes,Changgee Chang,Aman Prasad,Kevin Chorath,Seerat K. Poonia,Carolyn M. Jenks,Andrés M. Bur,Punam Thakkar,Evan M. Graboyes,Rahul Seth,Samuel Trosman,Anni Wong,Benjamin M. Laitman,Brianna Harris,Janki Shah,Vanessa C. Stubbs,Garret Choby,Qi Long,Christopher H. Rassekh,Erica R. Thaler,Karthik Rajasekaran +21 more
TL;DR: Otolaryngologists are among the highest risk for COVID‐19 exposure, according to a study published in JAMA Oncology.
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Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions
Candice Chapouly,Azeb Tadesse Argaw,Sam Horng,Kamilah Castro,Jingya Zhang,Linnea Asp,Hannah Loo,Benjamin M. Laitman,John N. Mariani,Rebecca Straus Farber,Elena Zaslavsky,German Nudelman,Cedric S. Raine,Gareth R. John +13 more
TL;DR: Data identify thymidine phosphorylase (TYMP) as an astrocyte-derived permeability factor, and suggest TYMP and VEGFA together promote blood-brain barrier breakdown.