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Benjamin P. Soule
Researcher at National Institutes of Health
Publications - 24
Citations - 1867
Benjamin P. Soule is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Internal medicine & Randomized controlled trial. The author has an hindex of 15, co-authored 20 publications receiving 1725 citations. Previous affiliations of Benjamin P. Soule include Thomas Jefferson University.
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Journal ArticleDOI
Residual NADPH oxidase and survival in chronic granulomatous disease.
Douglas B. Kuhns,W. Gregory Alvord,Theo Heller,Jordan J. Feld,Kristen M. Pike,Beatriz E. Marciano,Gulbu Uzel,Suk See DeRavin,Debra A. Long Priel,Benjamin P. Soule,Kol A. Zarember,Harry L. Malech,Steven M. Holland,John I. Gallin +13 more
TL;DR: The production of residual ROI is predicted by the specific NADPH oxidase mutation, regardless of the specific gene affected, and it is a predictor of survival in patients with chronic granulomatous disease.
Journal ArticleDOI
The Chemistry and Biology of Nitroxide Compounds
Benjamin P. Soule,Fuminori Hyodo,Ken-ichiro Matsumoto,Nicole L. Simone,John A. Cook,Murali C. Krishna,James B. Mitchell +6 more
TL;DR: The therapeutic and research uses of nitroxide compounds are reviewed here with a focus on the progress from initial development to modern trials.
Journal ArticleDOI
Ionizing radiation-induced oxidative stress alters miRNA expression.
Nicole L. Simone,Benjamin P. Soule,David Ly,Anthony Saleh,Jason E. Savage,William DeGraff,John A. Cook,Curtis C. Harris,David Gius,James B. Mitchell +9 more
TL;DR: A common miRNA expression signature in response to exogenous genotoxic agents including radiation, H2O2, and etoposide is demonstrated, implying that miRNAs play a role in cellular defense against exogenous stress and are involved in the generalized cellular response togenotoxic oxidative stress.
Journal ArticleDOI
Therapeutic and clinical applications of nitroxide compounds.
Benjamin P. Soule,Fuminori Hyodo,Ken-ichiro Matsumoto,Nicole L. Simone,John A. Cook,Murali C. Krishna,James B. Mitchell +6 more
TL;DR: The therapeutic and research uses of nitroxides are reviewed here, with a focus on the progress from initial development to modern, state-of-the art trials.
Journal ArticleDOI
Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53.
Anthony Saleh,Jason E. Savage,Liu Cao,Benjamin P. Soule,David Ly,William DeGraff,Curtis C. Harris,James B. Mitchell,Nicole L. Simone +8 more
TL;DR: It is demonstrated that let-7a andLet-7b expression decreases significantly following exposure to agents that induce stress including ionizing radiation, and this process may be a molecular target for anticancer agents.