N
Nicole L. Simone
Researcher at Thomas Jefferson University
Publications - 109
Citations - 5352
Nicole L. Simone is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 33, co-authored 93 publications receiving 4681 citations. Previous affiliations of Nicole L. Simone include National Institutes of Health & Rutgers University.
Papers
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Journal ArticleDOI
Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front
Cloud P. Paweletz,Cloud P. Paweletz,Cloud P. Paweletz,Lu Charboneau,Verena E. Bichsel,Verena E. Bichsel,Nicole L. Simone,Tina Chen,John W. Gillespie,Michael R. Emmert-Buck,Mark J. Roth,Emanuel F. Petricoin,Lance A. Liotta +12 more
TL;DR: Using this novel protein microarray, the state of pro-survival checkpoint proteins at the microscopic transition stage from patient matched histologically normal prostate epithelium to prostate intraepithelial neoplasia and then to invasive prostate cancer is longitudinally analysed.
Journal ArticleDOI
Laser-capture microdissection: opening the microscopic frontier to molecular analysis
TL;DR: Laser capture microdissection (LCM) has been developed to provide a reliable method to procure pure populations of cells from specific microscopic regions of tissue sections, in one step, under direct visualization.
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The Chemistry and Biology of Nitroxide Compounds
Benjamin P. Soule,Fuminori Hyodo,Ken-ichiro Matsumoto,Nicole L. Simone,John A. Cook,Murali C. Krishna,James B. Mitchell +6 more
TL;DR: The therapeutic and research uses of nitroxide compounds are reviewed here with a focus on the progress from initial development to modern trials.
Journal ArticleDOI
Ionizing radiation-induced oxidative stress alters miRNA expression.
Nicole L. Simone,Benjamin P. Soule,David Ly,Anthony Saleh,Jason E. Savage,William DeGraff,John A. Cook,Curtis C. Harris,David Gius,James B. Mitchell +9 more
TL;DR: A common miRNA expression signature in response to exogenous genotoxic agents including radiation, H2O2, and etoposide is demonstrated, implying that miRNAs play a role in cellular defense against exogenous stress and are involved in the generalized cellular response togenotoxic oxidative stress.
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COVID-19 medical papers have fewer women first authors than expected.
TL;DR: The results of an analysis that compared the gender distribution of authors on 1893 medical papers related to the pandemic with that on papers published in the same journals in 2019, for papers with first authors and last authors from the United States are consistent with the idea that the research productivity of women, especially early-career women, has been affected more than theResearch productivity of men.