D
David Gius
Researcher at Northwestern University
Publications - 156
Citations - 14524
David Gius is an academic researcher from Northwestern University. The author has contributed to research in topics: SIRT3 & Oxidative stress. The author has an hindex of 62, co-authored 152 publications receiving 12855 citations. Previous affiliations of David Gius include Seoul National University & Vanderbilt University Medical Center.
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Journal ArticleDOI
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Wenqiang Yu,David Gius,Patrick Onyango,Kristi Muldoon-Jacobs,Judith E. Karp,Andrew P. Feinberg,Hengmi Cui +6 more
TL;DR: It is shown that many TSGs have nearby antisense RNAs, and an inverse relation between p15 antisense (p15AS) and p15 sense expression in leukaemia is found, which suggests natural antisense RNA may be a trigger for heterochromatin formation and DNA methylation in TSG silencing in tumorigenesis.
Journal ArticleDOI
Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress
Randa Tao,Mitchell C. Coleman,J. Daniel Pennington,Özkan Özden,Seong Hoon Park,Haiyan Jiang,Hyun Seok Kim,Charles R. Flynn,Salisha Hill,W. Hayes McDonald,Alicia K. Olivier,Douglas R. Spitz,David Gius +12 more
TL;DR: Infestation of Sirt3⁻/⁻ MEFs with lenti-MnSOD(K122-R) inhibited in vitro immortalization by an oncogene (Ras), inhibited IR-induced genomic instability, and decreased mitochondrial superoxide, suggesting acetylation directly regulates function.
Journal ArticleDOI
SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
Hyun-Seok Kim,Krish Patel,Kristi Muldoon-Jacobs,Kheem S. Bisht,Nukhet Aykin-Burns,J. Daniel Pennington,Riet van der Meer,Phuongmai Nguyen,Jason E. Savage,Kjerstin M. Owens,Athanassios Vassilopoulos,Özkan Özden,Seong Hoon Park,Keshav K. Singh,Sarki A. Abdulkadir,Douglas R. Spitz,Chu-Xia Deng,David Gius +17 more
TL;DR: These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor and human breast and other human cancer specimens exhibit reduced Sirt3 levels.
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Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.
TL;DR: Evidence supporting the concept that perturbations in intracellular metabolic oxidation/reduction reactions contribute to the biological effects of radiation exposure is focused on as well as new concepts emerging from the field of free radical biology that may be relevant to future studies in radiobiology.
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Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice
Clara Bien Peek,Alison H. Affinati,Kathryn Moynihan Ramsey,Hsin Yu Kuo,Hsin Yu Kuo,Wei Yu,Laura A. Sena,Olga Ilkayeva,Biliana Marcheva,Yumiko Kobayashi,Chiaki Omura,Daniel C. Levine,David J. Bacsik,David Gius,Christopher B. Newgard,Eric S. Goetzman,Navdeep S. Chandel,John M. Denu,Milan Mrksich,Milan Mrksich,Joseph Bass +20 more
TL;DR: The results show that the circadian clock generates oscillations in mitochondrial oxidative capacity through rhythmic regulation of NAD+ biosynthesis, and facilitates oxidative rhythms that correspond with the fasting-feeding cycle to maximize energy production during rest.