B
Benjamin T. Weaver
Researcher at University of Alabama at Birmingham
Publications - 5
Citations - 692
Benjamin T. Weaver is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: T cell & Gene. The author has an hindex of 5, co-authored 5 publications receiving 544 citations.
Papers
More filters
Journal ArticleDOI
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage.
Ryuta Mukasa,Anand Balasubramani,Yun Kyung Lee,Sarah K. Whitley,Benjamin T. Weaver,Yoichiro Shibata,Gregory E. Crawford,Robin D. Hatton,Casey T. Weaver +8 more
TL;DR: It is found that Th17 cell precursors had substantial remodeling of the Ifng locus, but underwent critical additional modifications to enable high expression when stimulated by IL-12, and support a model of Th 17 cell lineage plasticity in which cell-extrinsic factors modulate Th17 Cell fates through differential effects on the epigenetic status of Th17cell lineage factors.
Journal ArticleDOI
Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells
Daniel DiToro,Colleen J. Winstead,Duy Pham,Steven Witte,Rakieb Andargachew,Jeffrey R. Singer,C. Garrett Wilson,Carlene L. Zindl,Rita J. Luther,Daniel J. Silberger,Benjamin T. Weaver,E. Motunrayo Kolawole,Ryan J. Martinez,Henrietta Turner,Robin D. Hatton,James J. Moon,Sing Sing Way,Brian D. Evavold,Casey T. Weaver +18 more
TL;DR: It is shown that naïve CD4+ T cells that produce IL-2 are fated to become TFH cells, whereas nonproducers, which receive IL-1, become non-TFH cells; a possible relationship between IL- 2 production and effector cell fate determination is investigated.
Journal ArticleDOI
Genomic diagnosis for children with intellectual disability and/or developmental delay
Kevin M. Bowling,Michelle L. Thompson,Michelle D. Amaral,Candice R. Finnila,Susan M. Hiatt,Krysta L. Engel,J. Nicholas Cochran,Kelly M. East,David E. Gray,Whitley V. Kelley,Neil E. Lamb,Edward J. Lose,Carla A. Rich,Shirley Simmons,Jana Whittle,Benjamin T. Weaver,Amy S. Nesmith,Richard M. Myers,Gregory S. Barsh,E. Martina Bebin,Gregory M. Cooper +20 more
TL;DR: The data strongly support the value of large-scale sequencing, especially WGS within proband-parent trios, as both an effective first-choice diagnostic tool and means to advance clinical and research progress related to pediatric neurological disease.
Journal ArticleDOI
Restricted Clonal Expression of IL-2 By Naive T Cells Reflects Differential Dynamic Interactions with Dendritic Cells
Vincent Hurez,Arman Saparov,Albert Tousson,Michael J. Fuller,Takekazu Kubo,James R. Oliver,Benjamin T. Weaver,Casey T. Weaver +7 more
TL;DR: There is intrinsic variability in clonal T cell populations that restrictsIL-2 commitment, and prolonged engagement with mature DCs is necessary, but not sufficient, for IL-2 gene transcription.
Posted ContentDOI
Genomic diagnosis for children with intellectual disability and/or developmental delay
Kevin M. Bowling,Michelle L. Thompson,Michelle D. Amaral,Candice R. Finnila,Susan M. Hiatt,Krysta L. Engel,J. Nicholas Cochran,Kelly M. East,David E. Gray,Whitley V. Kelley,Neil E. Lamb,Edward J. Lose,Carla A. Rich,Shirley Simmons,Jana Whittle,Benjamin T. Weaver,Amy S. Nesmith,Richard M. Myers,Gregory S. Barsh,E. Martina Bebin,Gregory M. Cooper +20 more
TL;DR: The data strongly support the value of large-scale sequencing, especially WGS within proband-parent trios, as both an effective first-choice diagnostic tool and means to advance clinical and research progress related to pediatric neurological disease.