D
Daniel DiToro
Researcher at Brigham and Women's Hospital
Publications - 19
Citations - 2699
Daniel DiToro is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 12 publications receiving 2262 citations. Previous affiliations of Daniel DiToro include Harvard University & La Jolla Institute for Allergy and Immunology.
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Journal ArticleDOI
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation.
Robert J. Johnston,Amanda C. Poholek,Daniel DiToro,Isharat Yusuf,Danelle Eto,Burton E. Barnett,Alexander L. Dent,Joe Craft,Shane Crotty,Shane Crotty +9 more
TL;DR: It is found that expression of the transcription factor Bcl6 in CD4+ T cells is both necessary and sufficient for in vivo TFH differentiation and T cell help to B cells in mice, and that Bcl 6 and Blimp-1 play central but opposing roles inTFH differentiation.
Journal ArticleDOI
IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation
Danelle Eto,Christopher Lao,Daniel DiToro,Burton E. Barnett,Tania C. Escobar,Robin Kageyama,Isharat Yusuf,Shane Crotty +7 more
TL;DR: It is indicated that optimal Tfh formation requires IL-21 and IL-6, and that cytokines alone are insufficient to drive T fh differentiation.
Journal ArticleDOI
Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150).
Isharat Yusuf,Robin Kageyama,Laurel A. Monticelli,Robert J. Johnston,Robert J. Johnston,Daniel DiToro,Kyle Hansen,Burton E. Barnett,Shane Crotty,Shane Crotty +9 more
TL;DR: It is demonstrated that GC-associated T follicular helper (GC TFH) cells can be identified by their coexpression of CXCR5 and the GL7 epitope, allowing for phenotypic and functional analysis of TFH and GC TFH populations.
Journal ArticleDOI
Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells
Daniel DiToro,Colleen J. Winstead,Duy Pham,Steven Witte,Rakieb Andargachew,Jeffrey R. Singer,C. Garrett Wilson,Carlene L. Zindl,Rita J. Luther,Daniel J. Silberger,Benjamin T. Weaver,E. Motunrayo Kolawole,Ryan J. Martinez,Henrietta Turner,Robin D. Hatton,James J. Moon,Sing Sing Way,Brian D. Evavold,Casey T. Weaver +18 more
TL;DR: It is shown that naïve CD4+ T cells that produce IL-2 are fated to become TFH cells, whereas nonproducers, which receive IL-1, become non-TFH cells; a possible relationship between IL- 2 production and effector cell fate determination is investigated.
Journal ArticleDOI
Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsis
Jeffrey R. Singer,Emily G. Blosser,Emily G. Blosser,Carlene L. Zindl,Daniel J. Silberger,Sean Conlan,Vincent A. Laufer,Daniel DiToro,Clay Deming,Ranjit Kumar,Casey D. Morrow,Julia A. Segre,Michael J. Gray,David A. Randolph,Casey T. Weaver +14 more
TL;DR: It is found that components of the developing microbiome were both necessary and sufficient to prevent late-onset sepsis in mice, and a basis for rational selection of probiotics that modulate primary succession of the microbiome to prevent disease.