Benoit Barbeau

TL;DR: It is shown that the viral Tax protein upregulates antisense transcription through its action on the TRE sequences located in the 3′ long terminal repeat in the HTLV-1 genome.

TL;DR: This study provides the first detection of antisense protein (ASP) in mammalian cells by Western blotting and suggests ASP-induced autophagy might explain the inherent difficulty in detecting this viral protein and might justify its presumed low abundance in infected cells.

TL;DR: It is demonstrated that galectin-1 expression and release are higher in HTLV-I-infected T cells in comparison to uninfecting T cells, and that this modulation could play an important role in HT LV-I infection by stabilizing both cell-to-cell and virus-cell interactions.

TL;DR: Exposure of leukemic T cells and human peripheral blood mononuclear cells to bis-peroxovanadium PTP inhibitors markedly induce activation and nuclear translocation of NFAT and it is proposed that this activation is participating in HIV-1 LTR stimulation by PTP inhibition.

TL;DR: Among the Cas-Br-E-induced non-T-, non-B-cell leukemias, viral integrations were found in the Fli-1 and Evi- 1 region in 71% (36 out of 51) and 22% (16 out of 72) of the tumors analyzed, respectively, suggesting that the formation of these MCF recombinants is not essential for activation of Fli, and that ecotropic Cas- Br-E already possesses the required sequences