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Benoit de Crombrugghe
Researcher at University of Texas MD Anderson Cancer Center
Publications - 148
Citations - 25751
Benoit de Crombrugghe is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Chondrocyte & Cellular differentiation. The author has an hindex of 75, co-authored 148 publications receiving 24008 citations. Previous affiliations of Benoit de Crombrugghe include National Institutes of Health & University of Texas at Austin.
Papers
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Journal ArticleDOI
Transcriptional mechanisms controlling types I and III collagen genes
Benoit de Crombrugghe,Gerard Karsenty,Sankar N. Maity,Tuula Vuorio,Pellegrino Rossi,E. Cristy Ruteshouser,Sandra McKinney,Guillermina Lozano +7 more
TL;DR: Investigation of the mechanisms that control the tissue-specific expression of these genes as well as the mechanisms by which effectors such as TGF-fl and other influence the mechanism of changes in synthesis of types I and I11 collagen.
Journal ArticleDOI
Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx.
TL;DR: Quantitative real-time RT-PCR results demonstrated that Dkk1 expression was downregulated in Osx-null calvaria at two different points of E15.5 and E18.5 in mice embryos, suggesting that Osx may target DKK1 directly, and supported the hypothesis that Dikk1 is a direct target of Osx.
Journal ArticleDOI
Downregulation of a rheumatoid arthritis-related antigen (RA-A47) by ra-a47 antisense oligonucleotides induces inflammatory factors in chondrocytes.
Takako Hattori,Takako Hattori,Harumi Kawaki,Satoshi Kubota,Yasutaka Yutani,Benoit de Crombrugghe,Klaus von der Mark,Klaus von der Mark,Masaharu Takigawa +8 more
TL;DR: Treatment of rabbit chondrocyes and human chondrosarcoma cells HCS‐2/8 by ra‐a47 antisense S‐oligonucleotides significantly reduced the expression of ra‐ a47 both at mRNA and protein level, indicating that downregulation of RA‐A47 induces TNFα‐independent cartilage‐degrading pathways involving iNOS and MMP‐9.
Book ChapterDOI
Purification, characterization, and role of CCAAT-binding factor in transcription
TL;DR: Results indicated that CBF is a transcription factor that can activate various eukaryotic genes and requires a high degree of conservation of the CCAAT sequence.