B
Boris Bleijlevens
Researcher at University of Amsterdam
Publications - 34
Citations - 2143
Boris Bleijlevens is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Active site & Hydrogenase. The author has an hindex of 20, co-authored 33 publications receiving 1813 citations. Previous affiliations of Boris Bleijlevens include Imperial College London.
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Journal ArticleDOI
Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation.
Laween Uthman,Antonius Baartscheer,Boris Bleijlevens,Cees A. Schumacher,Jan W.T. Fiolet,Anneke Koeman,Milena Jancev,Markus W. Hollmann,Nina C. Weber,Ruben Coronel,Coert J. Zuurbier +10 more
TL;DR: EMPA, DAPA and CANA directly inhibit cardiac NHE flux and reduce [Na+]c, possibly by binding with the Na+-binding site of NHE-1, and affect the healthy heart by inducing vasodilation.
Journal ArticleDOI
Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention.
Rolf G. Boot,Marri Verhoek,Maaike de Fost,Carla E. M. Hollak,Mario Maas,Boris Bleijlevens,Mariëlle J. van Breemen,Marjan van Meurs,Leonie A. Boven,Jon D. Laman,Mary Teresa Moran,Timothy M. Cox,Johannes M. F. G. Aerts +12 more
TL;DR: In this paper, the potential physiologic consequences of chronically elevated CCL18 levels in patients with Gaucher disease are discussed, as well as the potential pharmacologic consequences associated with chronically elevated levels.
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Ultrasensitive in situ visualization of active glucocerebrosidase molecules
Martin D. Witte,Wouter W. Kallemeijn,Jan Aten,Kah-Yee Li,Anneke Strijland,Wilma E. Donker-Koopman,Adrianus M. C. H. van den Nieuwendijk,Boris Bleijlevens,Gert Jan Kramer,Bogdan I. Florea,Berend Hooibrink,Carla E. M. Hollak,Roelof Ottenhoff,Rolf G. Boot,Gijsbert A. van der Marel,Herman S. Overkleeft,Johannes M. F. G. Aerts +16 more
TL;DR: The design, synthesis and application of two fluorescent activity-based probes allowing highly specific labeling of active GBA molecules in vitro and in cultured cells and mice in vivo are reported, allowing them to study inhibitors and tentative chaperones in living cells.
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Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis
Tom Seijkens,Claudia M. van Tiel,Pascal J. H. Kusters,Dorothee Atzler,Oliver Soehnlein,Barbara Zarzycka,Suzanne A. B. M. Aarts,Marnix Lameijer,Marion J.J. Gijbels,Linda Beckers,Myrthe den Toom,Bram Slütter,Johan Kuiper,Johan Duchene,Maria Aslani,Remco T. A. Megens,Cornelis van 't Veer,Gijs Kooij,Roy Schrijver,Marten A. Hoeksema,Louis Boon,Francois Fay,Jun Tang,Samantha Baxter,Aldo Jongejan,Perry D. Moerland,Gert Vriend,Boris Bleijlevens,Edward A. Fisher,Raphaël Duivenvoorden,Norbert Gerdes,Menno P.J. de Winther,Gerry A. F. Nicolaes,Willem J. M. Mulder,Christian Weber,Esther Lutgens +35 more
TL;DR: TRAF-STOPs can overcome the current limitations of long-term CD40 inhibition in Atherosclerosis and have the potential to become a future therapeutic for atherosclerosis.
Journal ArticleDOI
1001 Ways to run AutoDock Vina for virtual screening
TL;DR: In this article, the authors evaluate the performance of a specific tool, AutoDock Vina, on grid, Hadoop, small cluster and multi-core (virtual machine on the cloud).